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Chemical Compound Review:

Luperco 2-(2-phenylpropan-2- ylperoxy)propan-2...

Synonyms: Luperox, Di-cupr, Di-Cup, Kayacumyl D, Percumyl D, ...

Kensler, T. et al., Kurtz, S.M. et al., Hasegawa, T., Agadjanyan, Z.S. et al., Shichi, H. et al., et al.

Agadjanyan, Dugin, Dmitriev, Kurtz, Pruitt, Jewett, Foulds, Edidin,

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Disease relevance of Varox dcp-R

Dicumyl peroxide was a weak tumor promoter despite its high activity in inducing hyperplasia [1].

High impact information on Varox dcp-R

The enzyme shows no glutathione peroxidase activity with either H2O2 or cumene peroxide as substrate [2].
Cumene peroxide (CPO), BPO and known depressants such as phenobarbital and NaBr all stimulated GTPase activity in rat cerebral cortex synaptosomes [3].
Chemical crosslinking of UHMWPE was performed using 0.25% dicumyl peroxide (GHR 8110, GUR 1020 and 1050), and radiation crosslinking was performed using 150 kGy of electron beam radiation (GUR 1150) [4].
Cumene peroxide and Fe(2+)-ascorbate-induced lipid peroxidation and effect of phosphoglucose isomerase [5].
For example, skin tumor promoters such as tert-butyl hydroperoxide, cumene hydroperoxide, dicumyl peroxide and benzoyl peroxide undergo metal-dependent activation in keratinocytes to form alkoxyl, alkyl and aryl radicals as determined by spin trapping and electron paramagnetic resonance spectroscopy [6].

References

Comparison of the skin tumor-promoting potential of different organic peroxides in SENCAR mice. Gimenez-Conti, I.B., Binder, R.L., Johnston, D., Slaga, T.J. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
Purification and properties of anionic glutathione S-transferase from bovine ciliary body. Shichi, H., O'Meara, P.D. Biochem. J. (1986) [Pubmed]
Depressive effects of lipid peroxides mediated via a purine receptor. Effect of lipid peroxide on the cortical synaptosomal GTPase activity. Hasegawa, T. Biochem. Pharmacol. (1990) [Pubmed]
Radiation and chemical crosslinking promote strain hardening behavior and molecular alignment in ultra high molecular weight polyethylene during multi-axial loading conditions. Kurtz, S.M., Pruitt, L.A., Jewett, C.W., Foulds, J.R., Edidin, A.A. Biomaterials (1999) [Pubmed]
Cumene peroxide and Fe(2+)-ascorbate-induced lipid peroxidation and effect of phosphoglucose isomerase. Agadjanyan, Z.S., Dugin, S.F., Dmitriev, L.F. Mol. Cell. Biochem. (2006) [Pubmed]
Role of reactive intermediates in tumor promotion and progression. Kensler, T., Guyton, K., Egner, P., McCarthy, T., Lesko, S., Akman, S. Prog. Clin. Biol. Res. (1995) [Pubmed]

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