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Chemical Compound Review:

Benzofurazan 8-oxa-7,9- diazabicyclo[4.3.0]nona- 2,4,6,9...

Synonyms: benzofurazane, SureCN8380, PubChem22999, AG-K-72664, ACMC-209gwb, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Benzofurazan

Suppression of thiol exchange reaction in the determination of reduced-form thiols by high-performance liquid chromatography with fluorescence detection after derivatization with fluorogenic benzofurazan reagent, 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate and 4-aminosulfonyl-7-fluoro-2,1,3-benzoxadiazole [1].
(1)H-NMR studies of a mixture of model compound of CSP 1 and NBD-Ala suggest that the diastereomeric complex is composed of two hydrogen bonding sites at the amino proton and oxygen atom, and a pi-pi interaction by the benzofurazan structure (2,1,3-benzoxadiazole) of NBD-amino acid [2].
The synthesis of a potent benzothiadiazole analogue EMD 122801 together with in vitro studies of different methylendioxyphenyl, benzothiadiazole and benzofurazan derivatives is described [3].

Analytical, diagnostic and therapeutic context of Benzofurazan

Angiotensins, successfully derivatized with m-BS-ABD-F, a water-soluble fluorogenic reagent that has a 2,1,3-benzoxadiazole (benzofurazan) structure, could be simultaneously determined by coupled-column HPLC [4].
Total resolution of 17 DL-amino acids labelled with a fluorescent chiral reagent, R(-)-4-(3-isothiocyanatopyrrolidin-1-y1)-7-(N,N-dimethylaminosulfonyl)- 2,1,3-benzoxadiazole, by high-performance liquid chromatography [5].

References

Suppression of thiol exchange reaction in the determination of reduced-form thiols by high-performance liquid chromatography with fluorescence detection after derivatization with fluorogenic benzofurazan reagent, 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate and 4-aminosulfonyl-7-fluoro-2,1,3-benzoxadiazole. Santa, T., Aoyama, C., Fukushima, T., Imai, K., Funatsu, T. Biomed. Chromatogr. (2006) [Pubmed]
A study of chiral recognition for NBD-derivatives on a Pirkle-type chiral stationary phase. Kato, M., Fukushima, T., Shimba, N., Shimada, I., Kawakami, Y., Imai, K. Biomed. Chromatogr. (2001) [Pubmed]
Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster. Mederski, W.W., Osswald, M., Dorsch, D., Anzali, S., Christadler, M., Schmitges, C.J., Wilm, C. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
A method to evaluate the renin-angiotensin system in rat renal cortex using a microdialysis technique combined with HPLC-fluorescence detection. Kajiro, T., Nakajima, Y., Fukushima, T., Imai, K. Anal. Chem. (2002) [Pubmed]
Total resolution of 17 DL-amino acids labelled with a fluorescent chiral reagent, R(-)-4-(3-isothiocyanatopyrrolidin-1-y1)-7-(N,N-dimethylaminosulfonyl)- 2,1,3-benzoxadiazole, by high-performance liquid chromatography. Jin, D., Nagakura, K., Murofushi, S., Miyahara, T., Toyo'oka, T. Journal of chromatography. A. (1998) [Pubmed]

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