Disease relevance of NSC13139

• The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium [1].
• Distinction and characterization of Al species with differential toxicities were performed by two complementary speciation techniques; cation-exchange HPLC with fluorometric detection using 8-hydroxyquinoline-5-sulfonic acid (HQS) and size-fractionation/inductively coupled plasma atomic emission spectrometry (ICP-AES) [2].

High impact information on NSC13139

• The kinetics and equilibria of indium(III) binding to 8-quinolinol-5-sulfonic acid (HQSA) have been investigated in acidic aqueous solution at 0.2 M ionic strength and 25 C by stopped-flow, absorption and fluorescence spectrometric methods [3].
• The fluorescence of tin(IV) complexed by 8-hydroxyquinoline-5-sulfonic acid (8-HQSA) has been studied in both aqueous and hydroorganic (acetate buffer and dimethylsulfoxide) media [4].

Biological context of NSC13139

• Kinetics of the interaction of indium(III) with 8-quinolinol-5-sulfonic acid and with sulfate [3].

Associations of NSC13139 with other chemical compounds

• EDTA does not inhibit the enzyme; however, 8-hydroxyquinoline-5-sulfonic acid, o-phenanthroline, and 2,6-dipicolinic acid cause a time-dependent loss in activity which follows pseudo-first-order kinetics [5].

References