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Chemical Compound Review

Glycolamide     2-hydroxyethanamide

Synonyms: Glycollamide, AG-K-07531, ACMC-20ant9, CHEBI:30321, NSC-97323, ...
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Disease relevance of NSC97323


High impact information on NSC97323


Associations of NSC97323 with other chemical compounds

  • 2. Using gas chromatography-mass spectrometry, UK1 was identified as oxamic acid and UK2 as 2-hydroxyacetamide, confirming that PAO is involved in the metabolism of milacemide [6].
  • Stability studies of some glycolamide ester prodrugs of niflumic acid in aqueous buffers and human plasma by HPLC with UV detection [7].
  • The method is based on the conversion, via amidase activity, of glycollamide to glycollate which is growth inhibitory [1].
  • The glycolamide ester prodrugs of niflumic acid underwent chemical and enzymatic hydrolysis to release mainly the metabolite 2-(3-trifluoromethyl-phenylamino) nicotinic acid carboxymethyl ester (III) and not the parent drug 2-(3-trifluoromethyl-phenylamino)nicotinic acid [7].
  • Three types of mutant were isolated on lactate medium containing glycollamide: (i) mutants in which amidase activity was reduced or absent; (ii) double mutants that were amidase-negative and resistant to glycollate inhibition of growth; and (iii) glycollate-resistant mutants [1].

Gene context of NSC97323

  • By raising glycollamide concentrations in the selection medium, amidase-negative mutants were obtained from strains producing altered amidases with low specific acetamidase and glycollamidase activities [1].


  1. Isolation of amidase-negative mutants of Pseudomonas aeruginosa using glycollamide as a selective agent. Brown, P.R., Tata, R. J. Gen. Microbiol. (1987) [Pubmed]
  2. Microsomal N-hydroxylation of the glycolamide 2-(glycolylamino)fluorene to give the glycolylhydroxamic acid. A new xenobiotic reaction. Corbett, M.D., Corbett, B.R., Quintana, S.J., Hannothiaux, M.H., Wei, C.I. Chem. Res. Toxicol. (1990) [Pubmed]
  3. Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties. Nielsen, N.M., Bundgaard, H. Journal of pharmaceutical sciences. (1988) [Pubmed]
  4. Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors. Khanna, S., Madan, M., Vangoori, A., Banerjee, R., Thaimattam, R., Jafar Sadik Basha, S.K., Ramesh, M., Casturi, S.R., Pal, M. Bioorg. Med. Chem. (2006) [Pubmed]
  5. Prodrugs of scutellarin: Ethyl, benzyl and N,N-diethylglycolamide ester synthesis, physicochemical properties, intestinal metabolism and oral bioavailability in the rats. Cao, F., Guo, J.X., Ping, Q.N., Liao, Z.G. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2006) [Pubmed]
  6. Involvement of FAD-dependent polyamine oxidase in the metabolism of milacemide in the rat. Strolin Benedetti, M., Allievi, C., Cocchiara, G., Pevarello, P., Dostert, P. Xenobiotica (1992) [Pubmed]
  7. Stability studies of some glycolamide ester prodrugs of niflumic acid in aqueous buffers and human plasma by HPLC with UV detection. Talath, S., Shirote, P.J., Lough, W.J., Gadad, A.K. Arzneimittel-Forschung. (2006) [Pubmed]
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