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Chemical Compound Review:

AG-K-79715 3-hydroxy-4-methyl-cyclohexa- 2,4-diene-1,6...

Synonyms: SureCN7946964, NSC-106454, AC1Q6BVB, CTK5B3462, NSC106454, ...

Snellinx, Z. et al., Leungsakul, T. et al., Haigler, B.E. et al.

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Disease relevance of NSC106454

4-Methyl-5-nitrocatechol (4M5NC) monooxygenase (DntB) from Burkholderia sp. strain DNT catalyzes the second step of 2,4-dinitrotoluene degradation by converting 4M5NC to 2-hydroxy-5-methylquinone with the concomitant removal of the nitro group [1].
A second consortium member, Pseudomonas marginalis VM683 (consortium 1) and P. aeruginosa VM903, Sphingomonas sp. VM904, Stenotrophomonas maltophilia VM905 or P. viridiflava VM907 (consortium 2), was found to be indispensable for efficient growth of the consortia on 2,4-DNT and for efficient metabolisation of the intermediates 4M5NC and 2H5MQ [2].

High impact information on NSC106454

In the presence of NADPH and oxygen, MNC monooxygenase catalyzes the removal of the nitro group from MNC to form 2-hydroxy-5-methylquinone [3].

References

Protein engineering of the 4-methyl-5-nitrocatechol monooxygenase from Burkholderia sp. strain DNT for enhanced degradation of nitroaromatics. Leungsakul, T., Johnson, G.R., Wood, T.K. Appl. Environ. Microbiol. (2006) [Pubmed]
Microbial consortia that degrade 2,4-DNT by interspecies metabolism: isolation and characterisation. Snellinx, Z., Taghavi, S., Vangronsveld, J., van der Lelie, D. Biodegradation (2003) [Pubmed]
Purification and sequence analysis of 4-methyl-5-nitrocatechol oxygenase from Burkholderia sp. strain DNT. Haigler, B.E., Suen, W.C., Spain, J.C. J. Bacteriol. (1996) [Pubmed]

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