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Chemical Compound Review:

PubChem7472 (4-nitrophenyl)methanol

Synonyms: CPD-702, CHEMBL153580, SureCN114620, NSC-5389, ACMC-1AV5D, ...

Sartorius, C. et al., Ikeda, K. et al., Rhys-Williams, W. et al., Higashi, S. et al., James, K.D. et al.

Ikeda, Torisawa, Nishi, Minamikawa, Tanaka, Sato,

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Disease relevance of p-Nitrobenzyl alcohol

Cloning and expression of ntnD, encoding a novel NAD(P)(+)-independent 4-nitrobenzyl alcohol dehydrogenase from Pseudomonas sp. Strain TW3 [1].

High impact information on p-Nitrobenzyl alcohol

The principle was to measure the amount of p-nitrobenzyl alcohol released during ester hydrolysis using reversed-phase high performance liquid chromatography [2].
In the presence of the inhibitor isobutyramide, the pre-steady-state phase of alcohol (RCH2OH) oxidation at pH above 7 is characterized by the formation and decay of an intermediate with lambda max = 570, 640, and 672 nm for both aromatic and aliphatic alcohols (benzyl alcohol, p-nitrobenzyl alcohol, anisyl alcohol, ethanol, and methanol) [3].
The co-existence of two acid catalysts such as Bi(OTf)(3)-BF(3).OEt(2) or Bi(OTf)(3)-PPA is confirmed to be essential for obtaining high yields of glycosylation products with p-nitrobenzyl alcohol, which also turned to be superior to those reported previously [4].
HPLC analysis of culture supernatants showed that 4NBZ and 4NBZate were formed when 4NT-grown cells wer incubated with 4NBA, whereas only 4NBZate was found when they were incubated with 4NBZ [5].

References

Cloning and expression of ntnD, encoding a novel NAD(P)(+)-independent 4-nitrobenzyl alcohol dehydrogenase from Pseudomonas sp. Strain TW3. James, K.D., Hughes, M.A., Williams, P.A. J. Bacteriol. (2000) [Pubmed]
Tissue factor potentiates the factor VIIa-catalyzed hydrolysis of an ester substrate. Higashi, S., Nishimura, H., Fujii, S., Takada, K., Iwanaga, S. J. Biol. Chem. (1992) [Pubmed]
Active-site cobalt(II)-substituted horse liver alcohol dehydrogenase: characterization of intermediates in the oxidation and reduction processes as a function of pH. Sartorius, C., Gerber, M., Zeppezauer, M., Dunn, M.F. Biochemistry (1987) [Pubmed]
Glycosylation of sialyl acetates with a novel catalyst combination: bismuth triflate and BF3.OEt2 system. Ikeda, K., Torisawa, Y., Nishi, T., Minamikawa, J., Tanaka, K., Sato, M. Bioorg. Med. Chem. (2003) [Pubmed]
A novel pathway for the catabolism of 4-nitrotoluene by Pseudomonas. Rhys-Williams, W., Taylor, S.C., Williams, P.A. J. Gen. Microbiol. (1993) [Pubmed]

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