Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem10672 1-methyl-4-methylsulfanyl- benzene

Synonyms: SureCN76792, CPD-7698, NSC-6256, AG-K-82221, ACMC-209n23, ...

Pike, M.G. et al.

Pike, Martin, Mays, Benson, Naylor, Lipsky,

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High impact information on p-Methylphenyl methyl sulfide

We also showed that use of MTS sulfoxidation as an indicator of FMO activity in microsomes is valid only in the presence of a CYP450 inhibitor, such as NBI [1].
In the course of this work, methyl p-tolyl sulfide (MTS), sulfoxidation of which is used by some investigators as a specific probe for FMO activity, was found to be a substrate for both FMO and CYP450 in human liver microsomes [1].

References

Roles of FMO and CYP450 in the metabolism in human liver microsomes of S-methyl-N,N-diethyldithiocarbamate, a disulfiram metabolite. Pike, M.G., Martin, Y.N., Mays, D.C., Benson, L.M., Naylor, S., Lipsky, J.J. Alcohol. Clin. Exp. Res. (1999) [Pubmed]

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