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Chemical Compound Review:

CPD-28 1-methylpyrrole-2,5-dione

Synonyms: SureCN36966, CHEMBL225037, AG-K-67199, ACMC-209rjy, ANW-39980, ...

Guardia, T. et al., Reader, T.A. et al., Wuttke, W.A. et al., Higashida, H. et al.

Higashida, Hoshi, Knijnik, Zadina, Kastin,

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Disease relevance of NSC57594

4. EM-induced Ca2+ channel current inhibition was blocked by treatment or pretreatment of the cells with 100 microM N-methylmaleimide or 100 ng ml-1 pertussis toxin [1].

High impact information on NSC57594

8. N-methylmaleimide (0.5-1 mmol l-1), which blocks proton-pumping ATPase, produced a prolonged acidification of almost 1 pH unit, well beyond the level expected for simple equilibration with pHe [2].
It was found in this study that (a) pretreatment of rats with 1 (40 mg/kg, po) caused a significant increase in glycoprotein synthetic activity, approximately sevenfold as large as that of the control; and (b) pretreatment of the rats with the thiol reagent N-methylmaleimide (NEM) significantly diminished the cytoprotection provided by 1 [3].
Pretreatment of the membranes with the disulfide and sulfhydryl reactives DL-Dithiothreitol, L-Dithiothreitol, Dithioerythritol or 5',5'-Dithiobis-(2-nitrobenzoic acid) (DTNB), alone or in combination with the alkylating agent N-Methylmaleimide (NMM), decreased specific [3H]PRZ binding, with minor changes in the non-specific counts [4].

References

Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors. Higashida, H., Hoshi, N., Knijnik, R., Zadina, J.E., Kastin, A.J. J. Physiol. (Lond.) (1998) [Pubmed]
Intracellular pH of giant salivary gland cells of the leech Haementeria ghilianii: regulation and effects on secretion. Wuttke, W.A., Munsch, T., Berry, M.S. J. Exp. Biol. (1994) [Pubmed]
Mucus synthesis and sulfhydryl groups in cytoprotection mediated by dehydroleucodine, a sesquiterpene lactone. Guardia, T., Guzman, J.A., Pestchanker, M.J., Guerreiro, E., Giordano, O.S. J. Nat. Prod. (1994) [Pubmed]
Evidence for the participation of disulfide and sulfhydril groups in the specific binding of [3H]prazosin in cerebral cortex. Reader, T.A., Brière, R. Neurochem. Res. (1985) [Pubmed]

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