Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL475398 4-phenylbenzene-1,2-diol

Synonyms: SureCN928289, NSC-1267, AG-C-30829, CHEBI:49516, NSC1267, ...

Kuhm, A.E. et al., Halpaap-Wood, K. et al., Sietmann, R. et al.

Sietmann, Hammer, Moody, Cerniglia, Schauer,

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High impact information on NSC1267

1,2-Dihydroxynaphthalene dioxygenase from strain BN6 shows a wide substrate specificity and also cleaves 5-, 6-, and 7-hydroxy-1,2-dihydroxynaphthalene, 2,3- and 3,4-dihydroxybiphenyl, catechol, and 3-methyl- and 4-methylcatechol [1].
The initial hydroxylation favors the 4-position to produce 4-hydroxybiphenyl, which is subsequently hydroxylated to form 3,4-dihydroxybiphenyl [2].
In Sprague-Dawley rats, the effect of BNF induction was to increase greatly the biphenyl leads to 4-hydroxybiphenyl leads to 3,4-dihydroxybiphenyl pathway and to decrease the 4-hydroxy leads to 4,4'-dihydroxy conversion [3].

References

Purification and characterization of a 1,2-dihydroxynaphthalene dioxygenase from a bacterium that degrades naphthalenesulfonic acids. Kuhm, A.E., Stolz, A., Ngai, K.L., Knackmuss, H.J. J. Bacteriol. (1991) [Pubmed]
Hydroxylation of biphenyl by the yeast Trichosporon mucoides. Sietmann, R., Hammer, E., Moody, J., Cerniglia, C.E., Schauer, F. Arch. Microbiol. (2000) [Pubmed]
The effect of phenobarbital and beta-naphthoflavone induction on the metabolism of biphenyl in the rat and mouse. Halpaap-Wood, K., Horning, E.C., Horning, M.G. Drug Metab. Dispos. (1981) [Pubmed]

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