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Chemical Compound Review:

Sprodiamide 2-[bis[2-(carboxylatomethyl...

Synonyms: DyDTPA-BMA, MOLI001031, S-043, AC1L2HBD, AR-1I7083, ...

This record was replaced with 60755.

Saeed, M. et al., Kucharczyk, J. et al., Fossheim, S. et al., Lanens, D. et al., Saeed, M. et al., et al.

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Disease relevance of 2-[bis[2-(carboxymethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetic acid

CONCLUSION: Sprodiamide allows visualization of injection sites within enhanced infarction [1].
Perfusion deficits in areas of partial ischemia were seen more clearly on DyDTPA-BMA-enhanced images than after equimolar injections of GdDTPA-BMA [2].
OBJECTIVE: To assess the effects of Dy-DTPA-BMA (sprodiamide) on ex-vivo MR imaging of reperfused acute myocardial infarction [3].

High impact information on 2-[bis[2-(carboxymethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetic acid

Contrast-to-noise ratio in functional MRI of relative cerebral blood volume with sprodiamide injection [4].
In red blood cell suspensions (45% hematocrit, 37 degrees C, .47 T, 2 and 3 mM metal ion concentration), the T2 relaxation efficacy of DyDTPA-BMA was markedly improved due to susceptibility effects that were shown to depend on compartmentalization [5].
In the basal state, gadodiamide and sprodiamide equivalently altered the signal intensities of nonischemic myocardium and the territory of stenosed coronary artery [6].
On DE-prepared GRE sequences, administration of sprodiamide resulted in a substantial decrease in signal from normal myocardium and LV chamber blood in normal dogs [7].
Ten minutes after reperfusion, T1- and T2-weighted spin-echo (SE) images were obtained before and after administration of sprodiamide, gadodiamide, or both [8].

Chemical compound and disease context of 2-[bis[2-(carboxymethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetic acid

PURPOSE: To use (a) dysprosium-based contrast agent (sprodiamide) to confirm the site of myocardial injection and (b) T1-enhancing magnetic resonance (MR) contrast media to mark the myocardial target and T2*-enhancing contrast media to demonstrate injection sites in the margins or core of infarction on delayed contrast-enhanced images [1].

Analytical, diagnostic and therapeutic context of 2-[bis[2-(carboxymethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetic acid

Administration of 0.10-1.0 mmol/kg DyDTPA-BMA shortened the time for detection of perfusion deficits (residual hyperintensity) in 22 of 36 (61%) treated cats, often to within 30 min after arterial occlusion [2].
The evolution of a photochemically induced cortical infarct was monitored using T2-, postcontrast (GdDOTA) T1-, and postcontrast (DyDTPA-BMA) T2*-weighted NMR imaging techniques [9].

References

MR guidance of targeted injections into border and core of scarred myocardium in pigs. Saeed, M., Martin, A.J., Lee, R.J., Weber, O., Revel, D., Saloner, D., Higgins, C.B. Radiology. (2006) [Pubmed]
Cerebrovascular transit characteristics of DyDTPA-BMA and GdDTPA-BMA on normal and ischemic cat brain. Kucharczyk, J., Asgari, H., Mintorovitch, J., Vexler, Z., Rocklage, S., Watson, A., Moseley, M. AJNR. American journal of neuroradiology. (1993) [Pubmed]
Magnetic susceptibility of Dy-DTPA-BMA to reperfused myocardial infarction in an excised dog heart model: evidence of viable myocardium. Zhao, S., Revel, D., Arteaga, C., Canet, E., Liu, S., Hadour, G., Forrat, R., Oksendal, A. Chin. Med. J. (2000) [Pubmed]
Contrast-to-noise ratio in functional MRI of relative cerebral blood volume with sprodiamide injection. Lev, M.H., Kulke, S.F., Sorensen, A.G., Boxerman, J.L., Brady, T.J., Rosen, B.R., Buchbinder, B.R., Weisskoff, R.M. Journal of magnetic resonance imaging : JMRI. (1997) [Pubmed]
Low molecular weight lanthanide contrast agents: in vitro studies of mechanisms of action. Fossheim, S., Saebø, K.B., Fahlvik, A.K., Rongved, P., Klaveness, J. Journal of magnetic resonance imaging : JMRI. (1997) [Pubmed]
Quantification of the extent of area at risk with fast contrast-enhanced magnetic resonance imaging in experimental coronary artery stenosis. Saeed, M., Wendland, M.F., Szolar, D., Sakuma, H., Geschwind, J.F., Globits, S., Derugin, N., Higgins, C.B. Am. Heart J. (1996) [Pubmed]
First-pass contrast-enhanced inversion recovery and driven equilibrium fast GRE imaging studies: detection of acute myocardial ischemia. Saeed, M., Wendland, M.F., Lauerma, K., Sakuma, H., Chew, W., Derugin, N., Higgins, C.B. Journal of magnetic resonance imaging : JMRI. (1995) [Pubmed]
Detection of reperfused ischemia of the rat intestine: value of magnetic resonance imaging with small-molecular-weight dysprosium and gadolinium chelates. Van Beers, B.E., Goudemant, J.F., Oksendal, A., Jamart, J., Delos, M., Thiran, J.P., Demeure, R., Pringot, J., Maldague, B. Academic radiology. (1997) [Pubmed]
Complementary use of T2-weighted and postcontrast T1- and T2*-weighted imaging to distinguish sites of reversible and irreversible brain damage in focal ischemic lesions in the rat brain. Lanens, D., Spanoghe, M., Van Audekerke, J., Oksendal, A., Van der Linden, A., Dommisse, R. Magnetic resonance imaging. (1995) [Pubmed]

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