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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Myr-Gly-COOH     2-(tetradecanoylamino)ethanoic acid

Synonyms: AG-J-80016, HMDB13250, NSC-622050, AC1L2HWA, CTK4C3118, ...
 
 
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Disease relevance of NSC622050

  • These results show that targeting and accumulation of the HIV Gag precursor, Pr55gag, at the plasma membrane occurs in yeast in the absence of other viral components and requires the N-myristoyl-glycine residue [1].
 

High impact information on NSC622050

  • N-Myristoylglycine is released upon mild acid hydrolysis of myristoylated peptides and proteins and its derivitization to a p-nitrobenzylazlactone with subsequent analysis by reverse phase h.p.l.c. enabled its detection to pmol levels [2].
  • To develop a high-throughput assay for NMT, the principle of enzyme-linked immunosorbent assay (ELISA) is used, in which anti-N-myristoylglycine (anti-N-Myr-Gly) monoclonal antibody is utilized for the detection of the N-myristoylglycine moiety of the product of NMT catalysis [3].
 

Analytical, diagnostic and therapeutic context of NSC622050

References

 
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