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Chemical Compound Review

Uvaretin     1-[2,4-dihydroxy-3-[(2...

Synonyms: CHEMBL523296, CHEBI:9915, NCIMech_000569, AG-K-29891, CCG-35562, ...
 
 
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High impact information on C09978

  • Among the compounds isolated, uvaretin, diuvaretin, and (8',9'-dihydroxy)-3-farnesylindole were the most active (IC50 = 3.49, 4.20, and 2.86 micrograms/ml, respectively) [1].
  • Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7) [2].
  • Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin [3].

References

  1. Antimalarial activity of Tanzanian plants and their active constituents: the genus Uvaria. Nkunya, M.H., Weenen, H., Bray, D.H., Mgani, Q.A., Mwasumbi, L.B. Planta Med. (1991) [Pubmed]
  2. Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata. Ichimaru, M., Nakatani, N., Takahashi, T., Nishiyama, Y., Moriyasu, M., Kato, A., Mathenge, S.G., Juma, F.D., Nganga, J.N. Chem. Pharm. Bull. (2004) [Pubmed]
  3. Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin. Nakatani, N., Ichimaru, M., Moriyasu, M., Kato, A. Biol. Pharm. Bull. (2005) [Pubmed]
 
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