Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AD-288 (9R)-7-[(2S,4S,5S,6S)-4- (benzylamino)-5...

Synonyms: KST-1A7971, AC1Q6JJE, AR-1A4476, LS-183765, AD 288, ...

Traganos, F. et al., Lothstein, L. et al., Panta, G.R. et al.

Lothstein, Suttle, Roaten, Koseki, Israel, Sweatman,

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High impact information on N-Benzyladriamycin

We show that the anthracycline doxorubicin (DOX) and its congener N-benzyladriamycin (AD 288) selectively activate ATM and DNA-PK, respectively [1].
The two half-substituted congeners N-benzyladriamycin (AD288) and N,N-dimethyladriamycin (AD280) affected L1210 cell cycle traverse over a similar time scale at concentrations of 12.3 and 4.17 micrograms/ml, respectively [2].
Catalytic inhibition of DNA topoisomerase II by N-benzyladriamycin (AD 288) [3].
Since AD 288 is a potent DNA intercalator, catalytic inhibition is achieved by prohibiting access of the enzyme to DNA binding sites [3].

References

ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Panta, G.R., Kaur, S., Cavin, L.G., Cortés, M.L., Mercurio, F., Lothstein, L., Sweatman, T.W., Israel, M., Arsura, M. Mol. Cell. Biol. (2004) [Pubmed]
Effects of new N-alkyl analogues of adriamycin on in vitro survival and cell cycle progression of L1210 cells. Traganos, F., Israel, M., Silber, R., Seshadri, R., Kirschenbaum, S., Potmesil, M. Cancer Res. (1985) [Pubmed]
Catalytic inhibition of DNA topoisomerase II by N-benzyladriamycin (AD 288). Lothstein, L., Suttle, D.P., Roaten, J.B., Koseki, Y., Israel, M., Sweatman, T.W. Biochem. Pharmacol. (2000) [Pubmed]

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