Disease relevance of C10501

• Differentiation of human gastric adenocarcinoma cell line MGc80-3 induced by verbascoside [1].
• These results strongly indicate that verbascoside may provide a useful therapeutic strategy for the treatment of oxidative stress-induced neurodegenerative disease such as Parkinson's disease [2].
• Changes in phenolic composition induced by Pseudomonas savastanoi pv. Savastanoi infection in olive tree: presence of large amounts of verbascoside in nodules of tuberculosis disease [3].
• Mode of action of Buddleja cordata verbascoside against Staphylococcus aureus [4].

High impact information on C10501

• The scavenging activities of six phenylpropanoid glycosides, i.e. leucosceptoside A and martynoside, isolated from Pedicularis alashanica Maxim, verbascoside, and pediculariosides A, M and N isolated from Pedicularis striata Pall ssp. arachnoidea Franch Tsoong, on superoxide anion and hydroxyl radicals have been studied by the spin trapping method [5].
• Thus, the antitumor mechanism of verbascoside is demonstrated once more by its inhibiting effect on telomerase activity in tumor cells, and the telomerase assay may provide a valuable screening method for antitumor activity of natural products [6].
• These results suggest that verbascoside mediated-cell differentiation and apoptosis may be affected by telomere-telomerase-cell cycle dependent modulation [6].
• In vitro modulation of telomerase activity, telomere length and cell cycle in MKN45 cells by verbascoside [6].
• Protective effect of verbascoside on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells [2].

Biological context of C10501

• The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study [7].
• Compared with placebo group, there were lower MDA level (P < 0.05, 0.001, and 0.05 for days 3, 7, and 14, respectively) and higher erythrocyte membrane fluidity (P < 0.05, 0.001, and 0.001 for days 3, 7, and 14, respectively) in verbascoside group [7].
• Verbascoside might have the effects to moderate oxidative stress and erythrocyte membrane fluidity during immobilization [7].
• Verbascoside interacted with the catalytic domain of PKC and was a competitive inhibitor with respect to ATP (Ki = 22 microM) and a non-competitive inhibitor with respect to the phosphate acceptor (histone IIIS) [8].
• After 30 min pretreatment of the muscle, verbascoside at 20.0 microM resisted muscle fatigue significantly while martynoside at 80.0 microM improved muscle contractility only slightly [9].

Anatomical context of C10501

• Simultaneous treatment with verbascoside markedly attenuated MPP(+)-induced apoptotic death, increased extracellular hydrogen peroxide level, the activation of caspase-3 and the collapse of mitochondrial membrane potential [2].
• Effect of verbascoside on decreasing concentration of oxygen free radicals and lipid peroxidation in skeletal muscle [10].
• The in vitro immunomodulatory activity of verbascoside was investigated by assessing neutrophil function; chemotaxis and intracellular killing activity [11].

Associations of C10501 with other chemical compounds

• A reversed-phase high performance liquid chromatographic method has been developed for the determination of the main compounds (harpagoside, scorodioside, and verbascoside) from differents samples of SCROPHULARIA SCORODONIA [12].
• From the aerial parts of Marrubium alysson a new phenylpropanoid glycoside, alyssonoside, and five known glycosides, verbascoside (= acteoside), leucosceptoside A, martynoside, forsythoside B and leucosceptoside B were isolated [13].
• The goal of this study was to test whether the major polyphenolic compounds extracted from Ballota nigra, four phenylpropanoid glycosides, verbascoside, forsythoside B, arenarioside, and ballotetroside and one non-glycosidic phenylpropanoid, caffeoyl-L-malic acid, inhibit Cu(2+)-induced LDL peroxidation [14].
• When heroin-dependent mice were treated with verbascoside or luteolin, oxidative stress status was limited [15].
• The main chemotaxonomic markers of Scrophulariaceae, the iridoids aucubin, verbascoside and catalpol, were isolated [16].

Gene context of C10501

• Verbascoside is a natural antioxidant extracted from Pedicularis striata Pall (Jueyehesen) [1].
• After being treated with a 50 % inhibition concentration of verbascoside (17.8 microg/ml), telomerase activity in the cells was significantly inhibited but not in the cellular supernatant, the average telomere length became remarkably short, and the sub-G0 /G1 peak and G2/M arrest were also displayed when compared to the control cells [6].

Analytical, diagnostic and therapeutic context of C10501

• The rabbits in the verbascoside group were administrated with 0.8 mg/kg of verbascoside twice a day orally throughout the immobilization [7].
• Isolated rat hearts treated with alpha- or beta-adrenergic agents did not show significant reduction of the positive chronotropism, inotropism and increased coronary perfusion rate mediated by verbascoside [17].
• This study is to investigate the oxidative damage to DNA, proteins, and lipids in brain of mice administered heroin via intraperitoneal injection, and the effects of verbascoside and luteolin on this damage [15].
• The characterization of the major compounds in the extract as rutin, geniposide and verbascoside was performed by isolation and HPLC comparison with authentic samples [18].

References