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Chemical Compound Review:

Cumidene 4-propan-2-ylaniline

Synonyms: Cumidine, p-Cumidine, p-Aminocumene, SureCN5955, Cumidine (8CI), ...

Tixier, C. et al., Mostafa, F.I. et al.

Mostafa, Helling,

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Disease relevance of 1/C9H13N/c1-7(2)8-3-5-9(10)6-4-8/h3-7H,10H2,1-2H

According to the Microtox test (realized on the bacterium Vibrio fischeri), these metabolites presented non-target toxicity far more important (up to 600 times higher for 4-isopropylaniline) than the parent molecule [1].

High impact information on 1/C9H13N/c1-7(2)8-3-5-9(10)6-4-8/h3-7H,10H2,1-2H

Based on this, a degradation pathway is proposed, involving mono- and di-N-demethylation, hydroxylation of the isopropyl moiety, and hydrolysis to 4-isopropylaniline [2].

References

Biotransformation of phenylurea herbicides by a soil bacterial strain, Arthrobacter sp. N2: structure, ecotoxicity and fate of diuron metabolite with soil fungi. Tixier, C., Sancelme, M., Aït-Aïssa, S., Widehem, P., Bonnemoy, F., Cuer, A., Truffaut, N., Veschambre, H. Chemosphere (2002) [Pubmed]
Isoproturon degradation as affected by the growth of two algal species at different concentrations and pH values. Mostafa, F.I., Helling, C.S. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (2001) [Pubmed]

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