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Chemical Compound Review

Methylaniline     N-methylaniline

Synonyms: Anilinomethane, N-Methlaniline, SureCN4454, CHEMBL170781, NSC-3502, ...
 
 
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Disease relevance of N-methylaniline

 

High impact information on N-methylaniline

 

Biological context of N-methylaniline

 

Anatomical context of N-methylaniline

 

Associations of N-methylaniline with other chemical compounds

 

Gene context of N-methylaniline

 

Analytical, diagnostic and therapeutic context of N-methylaniline

  • HPLC examination of incubation mixtures revealed three UV-absorbing metabolites: N-methylaniline (4), N-cyclopropylaniline (6a), and a metabolite (M1) tentatively identified as p-hydroxy-2a, in a 2:5:2 mole ratio, respectively [16].

References

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  2. Characterization of the N-demethylation reactions catalyzed by horseradish peroxidase. Kedderis, G.L., Hollenberg, P.F. J. Biol. Chem. (1983) [Pubmed]
  3. The effect of substituents in the aromatic ring on carcinogenicity of N-nitrosomethylaniline in F344 rats. Kroeger-Koepke, M.B., Reuber, M.D., Iype, P.T., Lijinsky, W., Michejda, C.J. Carcinogenesis (1983) [Pubmed]
  4. Detection of monocyclic aromatic amines, possible mammary carcinogens, in human milk. DeBruin, L.S., Pawliszyn, J.B., Josephy, P.D. Chem. Res. Toxicol. (1999) [Pubmed]
  5. Enzymic N-demethylation reaction catalysed by red blood cell cytosol. Stecca, C., Cumps, J., Duverger-Van Bogaert, M. Biochem. Pharmacol. (1992) [Pubmed]
  6. Effect of dietary malathion on hepatic microsomal drug-metabolizing systems of Gallus domesticus. Varshneya, C., Bahga, H.S., Sharma, L.D. Toxicol. Lett. (1986) [Pubmed]
  7. The metabolism of N,N-dimethylaniline by isolated rat hepatocytes: identification of a novel N-conjugate. Sherratt, A.J., Damani, L.A. Xenobiotica (1989) [Pubmed]
  8. Oxidative N-demethylation of N,N-dimethylaniline by purified isozymes of cytochrome P-450. Pandey, R.N., Armstrong, A.P., Hollenberg, P.F. Biochem. Pharmacol. (1989) [Pubmed]
  9. Dietary effects on inhibition of rat hepatic microsomal drug-metabolizing enzymes by a pesticide (Morestan). Gaillard, D., Chamoiseau, G., Derache, R. Toxicology (1977) [Pubmed]
  10. Ionization of aniline and its N-methyl and N-phenyl substituted derivatives by (free) electron transfer to n-butyl chloride parent radical cations. Maroz, A., Hermann, R., Naumov, S., Brede, O. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  11. Studies of transalkylation of phosphotriesters in DNA: reaction conditions and requirements on nucleophiles for determination of DNA adducts. Haglund, J., Ehrenberg, L., Törnqvist, M. Chem. Biol. Interact. (1997) [Pubmed]
  12. A comparative study of pH/activity profiles for the anaerobic H2O2 and alkyl hydroperoxide supported N demethylation of N methylaniline catalyzed by alkaline haematin and microsomal cytochrome P-450. Adams, C., Adams, P.A. J. Inorg. Biochem. (1992) [Pubmed]
  13. Some effects of phenol- and thiol-nitrosation reactions on N-nitrosamine formation. Davies, R., Dennis, M.J., Massey, R.C., McWeeny, D.J. IARC scientific publications. (1978) [Pubmed]
  14. Model system studies on N-nitrosamine formation in relation to cured meat: the non-polar phase and S-nitroso peptides. Massey, R.C., Dennis, M.J., Crews, C., Davies, R., McWeeny, D.J. IARC Sci. Publ. (1980) [Pubmed]
  15. NIR vibrational overtone spectra of N-methylaniline, N,N-dimethylaniline and N,N-diethylaniline--a conformational structural analysis using local mode model. Shaji, S., Eappen, S.M., Rasheed, T.M., Nair, K.P. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2004) [Pubmed]
  16. Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine. Shaffer, C.L., Harriman, S., Koen, Y.M., Hanzlik, R.P. J. Am. Chem. Soc. (2002) [Pubmed]
 
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