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Chemical Compound Review:

Dioxolan (2,2-dimethyl-1,3-dioxolan-4- yl)methanol

Synonyms: Solketal, PubChem21305, SureCN23556, AC-364, ACMC-1AEDC, ...

Kamuhabwa, A.R. et al., Jongejan, A. et al., Pons, F. et al.

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Disease relevance of DIOXOLANE

Erythema, desquamation and erosions are demonstrated in the mice treated with hypericin in emulsifying ointment with solketal using a light dose of at least 4.5 J/cm2 [1].
Using a vehicle such as emulsifying ointment with solketal, it will be possible to explore the photo-activity of hypericin in the treatment of psoriasis and other skin diseases [1].
Deuterium isotope effect on enantioselectivity in the Comamonas testosteroni quinohemoprotein alcohol dehydrogenase-catalyzed kinetic resolution of rac-2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, solketal [2].

High impact information on DIOXOLANE

Hypericin is incorporated in either emulsifying ointment supplemented with solketal (hypericin content: 0.05%) or in polyethylene glycol (PEG) ointment (hypericin content: 0.5%) and applied to the skin of hairless mice for 4 h [1].
We investigated the effect of deuterium substitution on the enantiomeric ratio, E, of PQQ-containing quinohemoprotein alcohol dehydrogenase, QH-ADH, from Comamonas testosteroni in the ferricyanide-coupled kinetic resolution of rac-2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, solketal [2].
The dioxolan compound, BN 52111, dose-dependently reduced the bronchoconstriction (IC50 = 0.27 mg/kg) and at doses higher than 1 mg/kg partially antagonized the decrease in the number of circulating platelets and leukocytes induced by PAF [3].

References

Skin photosensitization with topical hypericin in hairless mice. Kamuhabwa, A.R., Roelandts, R., de Witte, P.A. J. Photochem. Photobiol. B, Biol. (1999) [Pubmed]
Deuterium isotope effect on enantioselectivity in the Comamonas testosteroni quinohemoprotein alcohol dehydrogenase-catalyzed kinetic resolution of rac-2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, solketal. Jongejan, A., Jongejan, J.A., Hagen, W.R. Biochim. Biophys. Acta (2003) [Pubmed]
Action of platelet-activating factor (PAF) antagonists on the bronchopulmonary effects of PAF in the guinea-pig. Pons, F., Touvay, C., Lejeune, V., Carré, C., Vilain, B., Broquet, C., Mencia-Huerta, J.M., Braquet, P. Journal of lipid mediators. (1989) [Pubmed]

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