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Chemical Compound Review:

ACMC-1CLFY tris(4-chlorophenyl)methanol

Synonyms: AG-J-99619, SureCN7434539, ANW-45121, AC-5735, AC1L2QSB, ...

Tiemann, U. et al., de Boer, J. et al., Minh, T.B. et al., Poon, R. et al., Kunisue, T. et al., et al.

Tiemann, Pöhland, Richter, Wollenhaupt,

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Disease relevance of EINECS 221-137-4

The systemic toxicity of tris(4-chlorophenyl)methanol (TCPM) was studied in male and female rats following 4 weeks dietary exposure dosed at 1, 10 and 100 ppm [1].

High impact information on EINECS 221-137-4

Specific accumulation and elimination kinetics of tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol, and other persistent organochlorines in humans from Japan [2].
Occurrence of Tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol, and some other persistent organochlorines in Japanese human adipose tissue [3].
Occurrence of PCBs, organochlorine insecticides, tris(4-chlorophenyl)methane, and tris(4-chlorophenyl)methanol in human breast milk collected from Cambodia [4].
Interaction between tris(4-chlorophenyl)methanol and the human androgen receptor in vitro [5].
Influence of tris(4-chlorophenyl)methanol (TCPM) on gap junction-mediated intercellular communication of cultured bovine granulosa cells [6].

Associations of EINECS 221-137-4 with other chemical compounds

Tris(4-chlorophenyl)methanol (TCPM) is a by-product in the manufacture of technical grade DDT, which is known to alter properties and functions of the female reproductive system [6].

Analytical, diagnostic and therapeutic context of EINECS 221-137-4

Tris(4-chlorophenyl)methanol (TCP) and tris(4-chlorophenyl)methane (TCPMe) were determined in aquatic organisms and sediment by a method based on Soxhlet extraction, gel permeation chromatography, fractionation over silica and gas chromatography/mass spectrometry (GC/MS) analysis [7].

References

Effects of tris(4-chlorophenyl)methanol on the rat following short-term oral exposure. Poon, R., Lecavalier, P., Bergman, A., Yagminas, A., Chu, I., Valli, V.E. Chemosphere (1997) [Pubmed]
Specific accumulation and elimination kinetics of tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol, and other persistent organochlorines in humans from Japan. Minh, T.B., Watanabe, M., Tanabe, S., Yamada, T., Hata, J., Watanabe, S. Environ. Health Perspect. (2001) [Pubmed]
Occurrence of Tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol, and some other persistent organochlorines in Japanese human adipose tissue. Minh, T.B., Watanabe, M., Tanabe, S., Yamada, T., Hata, J., Watanabe, S. Environ. Health Perspect. (2000) [Pubmed]
Occurrence of PCBs, organochlorine insecticides, tris(4-chlorophenyl)methane, and tris(4-chlorophenyl)methanol in human breast milk collected from Cambodia. Kunisue, T., Someya, M., Monirith, I., Watanabe, M., Tana, T.S., Tanabe, S. Arch. Environ. Contam. Toxicol. (2004) [Pubmed]
Interaction between tris(4-chlorophenyl)methanol and the human androgen receptor in vitro. Schrader, T.J., Cooke, G.M. Toxicol. Lett. (2002) [Pubmed]
Influence of tris(4-chlorophenyl)methanol (TCPM) on gap junction-mediated intercellular communication of cultured bovine granulosa cells. Tiemann, U., Pöhland, R., Richter, W., Wollenhaupt, K. Toxicology in vitro : an international journal published in association with BIBRA. (2002) [Pubmed]
Determination of tris(4-chlorophenyl)methanol and tris(4-chlorophenyl)methane in fish, marine mammals and sediment. de Boer, J., Wester, P.G., Evers, E.H., Brinkman, U.A. Environ. Pollut. (1996) [Pubmed]

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