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Chemical Compound Review:

SureCN4622 4-methylmorpholine

Synonyms: PubChem17627, NSC-9382, CCRIS 6691, M56557_ALDRICH, AG-C-84393, ...

Hansén, L. et al., Sitarek, K., Friedrich, H.B. et al., Holmén, A. et al.

Friedrich, Govender, Makhoba, Ngcobo, Onani,

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Disease relevance of 3651-67-0

Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats [1].
N-methylmorpholine induced anophthalmia, internal hydrocephalus, and hydronephrosis but only at one dose which was also maternotoxic [1].

High impact information on 3651-67-0

A new Os/Cu-Al-hydrotalcite-like catalyst is described which, with N-methylmorpholine oxide as co-oxidant, heterogeneously catalyses the hydroxylation of olefins to give diols selectively and in high yield [2].
Determination of N-methylmorpholine in air samples from a polyurethane foam factory. Comparison between two methods using gas chromatography and isotachophoresis for analysis [3].
The occupational exposure was monitored by measurements of toluene diisocyanate and N-methylmorpholine in work-room air [4].

Analytical, diagnostic and therapeutic context of 3651-67-0

Urine was collected from seven workers and analyzed for N-methylmorpholine by gas chromatography [3].

References

Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats. Sitarek, K. Teratog., Carcinog. Mutagen. (1999) [Pubmed]
The Os/Cu-Al-hydrotalcite catalysed hydroxylation of alkenes. Friedrich, H.B., Govender, M., Makhoba, X., Ngcobo, T.D., Onani, M.O. Chem. Commun. (Camb.) (2003) [Pubmed]
Determination of N-methylmorpholine in air samples from a polyurethane foam factory. Comparison between two methods using gas chromatography and isotachophoresis for analysis. Hansén, L., Akesson, B., Sollenberg, J., Lundh, T. Scandinavian journal of work, environment & health. (1986) [Pubmed]
Comparison among five mutagenicity assays in workers producing polyurethane foams. Holmén, A., Akesson, B., Hansén, L., Frithiof, J., Mitelman, F., Karlsson, A., Persson, L., Welinder, H., Skerfving, S., Högstedt, B. International archives of occupational and environmental health. (1988) [Pubmed]

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