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Chemical Compound Review:

SureCN93999 4-amino-2,6-dichloro-phenol

Synonyms: A48407_ALDRICH, AG-G-11128, ACMC-209mc4, ANW-33218, NSC-156835, ...

Rankin, G.O. et al., Lowe, E.R. et al., Valentovic, M.A. et al.

Valentovic, Rogers, Meadows, Conner, Williams, Hong, Rankin,

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Disease relevance of NSC 156835

These results demonstrate that 4-amino-2,6-dichlorophenol is a nephrotoxicant and hepatotoxicant in vivo and in vitro and that the kidney is more susceptible to 4-amino-2,6-dichlorophenol toxicity than the liver [1].

High impact information on NSC 156835

Methemoglobin generation in vitro was higher (P < 0.05) than control values in erythrocytes incubated for 30 min with 0.2-0.6 mM 4-amino-2,6-dichlorophenol or 5-100 microM 3,5-dichlorophenylhydroxylamine [2].
In the in vitro experiments, the effect of 4-amino-2,6-dichlorophenol on organic ion accumulation, gluconeogenesis and lactate dehydrogenase (LDH) leakage was quantitated in liver and/or renal cortical slices [1].
The purpose of this study was to determine the in vivo and in vitro nephrotoxic and hepatotoxic potential of 4-amino-2,6-dichlorophenol, a putative metabolite of 3,5-dichloroaniline [1].
The voltammetric behaviour of 2,6-dichloro-p-aminophenol (PAP) in aqueous solution at an edge plane pyrolytic graphite electrode was explored and its sensitivity to additions of substituted phenols examined [3].

Associations of NSC 156835 with other chemical compounds

Renal and hepatic pyruvate-stimulated gluconeogenesis were inhibited and renal LDH leakage increased at 4-amino-2,6-dichlorophenol bath concentrations of 5 x 10(-5) M or greater [1].

References

In vivo and in vitro 4-amino-2,6-dichlorophenol nephrotoxicity and hepatotoxicity in the Fischer 344 rat. Rankin, G.O., Valentovic, M.A., Nicoll, D.W., Ball, J.G., Anestis, D.K., Wang, R.T., Brown, P.I. Toxicology (1994) [Pubmed]
Characterization of methemoglobin formation induced by 3,5-dichloroaniline, 4-amino-2,6-dichlorophenol and 3,5-dichlorophenylhydroxylamine. Valentovic, M.A., Rogers, B.A., Meadows, M.K., Conner, J.T., Williams, E., Hong, S.K., Rankin, G.O. Toxicology (1997) [Pubmed]
Indirect detection of substituted phenols and cannabis based on the electrochemical adaptation of the Gibbs reaction. Lowe, E.R., Banks, C.E., Compton, R.G. Analytical and bioanalytical chemistry. (2005) [Pubmed]

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