Disease relevance of NSC4741

• Light-chain proteinuria: spurious false-negative reaction to sulfosalicylic acid [1].
• Values of total proteinuria measured by the sulfosalicylic acid method did not correlate with radial immunodiffusion measured albuminuria [2].

High impact information on NSC4741

• GABA was measured in CSF by a modification of the ion exchange-fluorometric method that featured use of a relatively large cation exchange column, and a markedly decreased quantity of sulfosalicylic acid for deproteinization of CSF [3].
• Our examination of urine components separated by gel filtration revealed the presence of an inhibitor that decreases the analytical recovery of protein in a turbidimetric assay involving sulfosalicylic acid as reagent (Proc. Soc. Exp. Biol. Med. 92: 748, 1956) [4].
• All other tested persons, the so-called non-malignant or healthy cases, had an inhibition of less than -5% or even an acceleration of the tanned sheep erythrocytes stabilized with sulfosalicylic acid (ETS) [5].
• Then serum protein precipitations by acetonitrile, acetone, sulfosalicylic acid, perchloric acid and trichloracetic acid, prior to derivatization by IAF, were also investigated [6].
• Finally, the pH variations did not significantly modify the activity of the SSA salts, suggesting that their greater activity could be due to better lipophilic activity of these compounds with respect to the nitrate salts [7].

Anatomical context of NSC4741

• METHODS: An equal volume of 6% sulfosalicylic acid was added to plasma aliquots at 0, 2, 4, 10, 16, 24, 36, 48, 60, and 72 hours after separation of blood cells [8].

Associations of NSC4741 with other chemical compounds

• The limits of determination of Gc subtypes in bloodstains were compared between the immunofixation method and the sulfosalicylic acid precipitation method using isoelectric focusing on polyacrylamide gel [9].
• Separations in a 20% acetonitrile-20 mM borate mixture (pH 9.9) are able to resolve all of the geometric isomers of hydroxybenzoic acid, phthalic acid, benzenetricarboxylic acid, and nitrophenol as well as 1,2,4,5-benzenetricarboxylic acid, m-toluic acid, and sulfosalicylic acid [10].

Gene context of NSC4741

• A method for myoglobin in cryostat sections of muscle by precipitation with sulfosalicylic acid [11].

Analytical, diagnostic and therapeutic context of NSC4741

• MEASUREMENTS: Random urine specimens were tested for albumin by using Micral-Test immunoassay strips (Boehringer Mannheim, Mannheim, Germany) and for protein by using sulfosalicylic acid testing and impregnated dipsticks (Chemstrips, Boehringer Mannheim) [12].
• When the same samples were reanalyzed after protein removal by sulfosalicylic acid precipitation, ultrafiltration, or more extensive dilution, the measured serum inorganic phosphate levels were invariably normal [13].
• SIP measurements of CSF total protein and albumin exhibited good linear correlation with the sulfosalicylic acid turbidimetric method for total protein and the radial immunodiffusion (RID) method for albumin [14].
• In order to evaluate the applicability of the method, three different types of sample were chromatographed, e.g. urine (obtained from healthy human volunteers), pig plasma and sulfosalicylic acid homogenates of pig intestine biopsies [15].
• Dilute HCl (10 mmol/L) has been used to lyse cells, before protein removal by centrifugation in the presence of 1.3% sulfosalicylic acid [16].

References