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Chemical Compound Review: 

AG-G-70868     1-methyl-4-nitro-5- phenoxysulfonyl-imidazole

Synonyms: NSC-38087, NSC38087, CTK5D0377, AR-1L0391, NSC 38087, ...
 
 
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Disease relevance of NSC 38087

  • In contrast to other nitro-heterocyclic radiosensitizers, NSC 38087 and related 5-substituted 4-nitroimidazoles show greater toxicity towards aerobic than to hypoxic cells [1].
  • Log-phase cells show the highest sensitivity to the toxic action of NSC 38087, with plateau-phase cells, cells with a history of chronic hypoxia, and thermotolerant cells showing greater resistance [1].

References

  1. Cytotoxic properties of a 4-nitroimidazole (NSC 38087): a radiosensitizer of hypoxic cells in vitro. Stratford, I.J., Williamson, C., Hardy, C. Br. J. Cancer (1981) [Pubmed]
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