Disease relevance of NSC 140721

• Endotoxin toxicity in rats with 6-sulfanilamidoindazole arthritis [1].
• 6-Sulfanilamidoindazole (6SAI) is known to induce not only an acute arthritis but also serositis and arteritis which resemble those induced by some vasodilators in rats [2].
• Arthritis was induced by daily subcutaneous administration of 6-sulfanilamidoindazole, an antibacterial sulfa known to produce an acute, self-limited arthritis and periarthritis in the hind paws of rats [3].

High impact information on NSC 140721

• Normal erythrocyte sedimentation rate with hyperfibrinogenemia in 6-sulfanilamidoindazole arthritis [4].
• The plasma fibrinogen concentration is usually increased in inflammatory disorders and is thought to contribute to the ESR elevation, 6-sulfanilamidoindazole induced arthritis in rats produces very high plasma fibrinogen concentrations and increased blood viscosity but no change in ESR [4].
• Endotoxin levels in the plasma from the abdominal aorta and portal vein from rats that had 6SAI (500 mg/kg) administered orally for up to 7 days remained within the control values at day 1 and day 3, and were significantly elevated at day 7 [5].

Analytical, diagnostic and therapeutic context of NSC 140721

• Seven oral administrations of 6-sulfanilamidoindazole (6-SAI) to 10- to 12-month-old rats sensitized the animals to endotoxin, with dosages as small as 2.5 microgram causing death in 80% of animals [1].

References