The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Mepanipyrim     4-methyl-N-phenyl-6-prop-1- ynyl-pyrimidin...

Synonyms: SureCN22040, AK-37723, CTK8E6991, LS-134497, AKOS015916777, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Mepanipyrim

  • We have previously reported that ingestion of mepanipyrim induces fatty liver in rats due to the inhibitory effect on the synthesis or secretion of hepatocytic very low density lipoproteins (VLDL) [1].
  • Mepanipyrim, N-(4-methyl-6-prop-1-ynylpyrimidin-2-yl)aniline, diminished the cell surface expression of envelope glycoproteins of Newcastle disease and vesicular stomatitis viruses at concentrations where their synthesis was not profoundly affected [2].
 

High impact information on Mepanipyrim

  • Mepanipyrim, a new fungicide, inhibits intracellular transport of very low density lipoprotein in rat hepatocytes [1].
  • The density of the VLDL-loaded secretory vacuoles isolated from the Golgi fractions was greater in mepanipyrim-treated rat livers compared with that in the control [1].
  • Immunofluorescence micrograph of rat hepatocytes stained with anti-alpha-tubulin monoclonal antibody demonstrated that mepanipyrim neither affected microtubule network nor changed the intracellular ATP level [1].
  • VLDL accumulation in the Golgi apparatus of the liver, especially in the secretory vacuoles, was observed in the treated rats and in the hepatocytes treated for 2 hr with 25 micrograms/ml mepanipyrim [1].
  • The OH substitution involves the aromatic and the heterocyclic ring and the nitrogen bridge between the two rings, except for mepanipyrim when the hydroxylation also involves the propynylic side chain [3].
 

Biological context of Mepanipyrim

 

Anatomical context of Mepanipyrim

  • Mepanipyrim also decreased serum concentrations of low-density lipoprotein (LDL) and high-density lipoprotein (HDL), and the relative weights of the epididymal adipose tissue, indicating that a reduction in serum VLDL does not reflect acceleration of serum VLDL dissimulation [4].
 

Gene context of Mepanipyrim

  • However, mepanipyrim did not block the TGN38 dispersion induced by any of these compounds [5].
  • Intoxication by diphtheria toxin and ricin and recycling of transferrin were not affected even when cells were treated with mepanipyrim for 2 h before the addition of these probes, indicating that mepanipyrim does not act on the endocytic and recycling pathways of these proteins [2].

References

  1. Mepanipyrim, a new fungicide, inhibits intracellular transport of very low density lipoprotein in rat hepatocytes. Terada, M., Mizuhashi, F., Murata, K., Tomita, T. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  2. Effects of mepanipyrim on intracellular trafficking: a comparative study on its effects on exocytic and endocytic trafficking of proteins, sphingolipids, and cholesterol. Miura, I., Muroi, M., Shiragami, N., Yamaguchi, I., Takatsuki, A. Biosci. Biotechnol. Biochem. (1996) [Pubmed]
  3. Degradation of anilinopyrimidine fungicides photoinduced by iron(III)-polycarboxylate complexes. Anfossi, L., Sales, P., Vanni, A. Pest Manag. Sci. (2006) [Pubmed]
  4. Effects of mepanipyrim on lipid metabolism in rats. Terada, M., Mizuhashi, F., Tomita, T., Murata, K. The Journal of toxicological sciences. (1998) [Pubmed]
  5. Mepanipyrim, a novel inhibitor of pharmacologically induced Golgi dispersion. Nakamura, M., Kono, Y., Takatsuki, A. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
 
WikiGenes - Universities