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Chemical Compound Review:

AA-2G (2R)-2-[(1S)-1,2- dihydroxyethyl]-5-hydroxy...

Synonyms:

Wu, Y.L. et al., Yanagida, M. et al., Mandai, T. et al., Yamamoto, I. et al., Wakamiya, H. et al.

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High impact information on L-Ascorbic acid 2-O-alpha-glucoside

Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid [1].
We examined the effects of ascorbic acid (AsA), which stimulates the proliferation of fibroblasts, and its stable derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), on HGF production by human skin fibroblasts [2].
In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper [3].
Determination of the molecular structure by single crystal X-ray analysis showed the compound to be 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G) [4].
In situ intestinal absorption of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid in guinea pigs [5].

References

Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid. Yamamoto, I., Muto, N., Murakami, K., Akiyama, J. J. Nutr. (1992) [Pubmed]
Stimulation of hepatocyte growth factor production by ascorbic acid and its stable 2-glucoside. Wu, Y.L., Gohda, E., Iwao, M., Matsunaga, T., Nagao, T., Takebe, T., Yamamoto, I. Growth Horm. IGF Res. (1998) [Pubmed]
Nerve growth factor enhances antigen-specific antibody production in ascorbate-stimulated murine splenocytes. Yanagida, M., Gohda, E., Yamamoto, I. Life Sci. (1996) [Pubmed]
The crystal structure and physicochemical properties of L-ascorbic acid 2-glucoside. Mandai, T., Yoneyama, M., Sakai, S., Muto, N., Yamamoto, I. Carbohydr. Res. (1992) [Pubmed]
In situ intestinal absorption of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid in guinea pigs. Wakamiya, H., Suzuki, E., Yamamoto, I., Akiba, M., Arakawa, N. J. Nutr. Sci. Vitaminol. (1995) [Pubmed]

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