Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

PubChem9840 5,7-dimethoxy-2-phenyl- chromen-4-one

Synonyms: Chrysin DME, CHEMBL275391, SureCN1676012, BSPBio_002847, KBioGR_001777, ...

Walle, T. et al., Tsuji, P.A. et al., Tsuji, P.A. et al., Sookkongwaree, K. et al., Wen, X. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C10029

The most effective inhibitors, 5-hydroxy-7-methoxyflavone and 5,7-dimethoxyflavone, inhibited HIV-1 protease with IC50 values of 19 microM [1].

High impact information on C10029

In this study, we used benzo[a]pyrene (BaP) as the classic PAH compound and BEAS-2B cells, a model of normal human bronchial epithelial cells, to investigate whether 5,7-dimethoxyflavone (5,7-DMF) and 3',4'-DMF compared with resveratrol (RV) have chemopreventive properties in this cancer [2].
5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells [3].
In the human oral SCC-9 cancer cells, 5,7-dimethoxyflavone and 5,7,4'-trimethoxyflavone were both 10 times more potent inhibitors of cell proliferation (IC(50) values 5-8muM) than the corresponding unmethylated analogs chrysin and apigenin [4].
Finally, we demonstrated that 5,7-dimethoxyflavone, in contrast to its unmethylated analog chrysin, was well absorbed and had high oral bioavailability as well as tissue accumulation in vivo in the rat [4].
One such compound, the naturally-occurring 5,7-dimethoxyflavone (5,7-DMF), has been shown to be a potential chemopreventive agent in human cancer originating from the liver, mouth, esophagus and lung [5].

References

Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora. Sookkongwaree, K., Geitmann, M., Roengsumran, S., Petsom, A., Danielson, U.H. Die Pharmazie. (2006) [Pubmed]
Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. Tsuji, P.A., Walle, T. Carcinogenesis (2006) [Pubmed]
5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells. Wen, X., Walle, U.K., Walle, T. Carcinogenesis (2005) [Pubmed]
Cancer chemopreventive properties of orally bioavailable flavonoids-Methylated versus unmethylated flavones. Walle, T., Ta, N., Kawamori, T., Wen, X., Tsuji, P.A., Walle, U.K. Biochem. Pharmacol. (2007) [Pubmed]
Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. Tsuji, P.A., Winn, R.N., Walle, T. Chem. Biol. Interact. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share