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Chemical Compound Review:

Haloart [2-[ (6R,8S,9S,10S,11S,13S,14S,17R) -17...

Synonyms: Haloart (TN), THS-201, SureCN25316, CCRIS 2685, CHEMBL2106520, ...

Rampini, E. et al., Yamashita, K. et al., Santoro, J.C. et al., Kiniwa, M. et al., Netti, C. et al., et al.

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Disease relevance of THS-201

The halopredone acetate results were identical to those of th excipient, although it was found that halopredone acetate cream (Topicon) had a marked anti-inflammatory effect in animals and on human dermatoses [1].
A fifty-two-week chronic toxicity study of halopredone acetate (THS-201) in dogs [2].

High impact information on THS-201

This assay can distinguish between partial agonists such as halopredone acetate and complete agonists such as prednisolone and measure the potency of known glucocorticoid receptor (GR) antagonists like mifepristone [3].
Comparative study of the vasoconstrictor activity of halopredone acetate in a modified McKenzie test [1].
In doses of 0.1, 0.5 and 2.5 mg/kg, THS-201 was injected into the right knee joint in both sexes of dogs every 2 weeks for 39 weeks and withdrawn for 13 weeks [2].
In rats, THS-201 (80 micrograms/pellet) completely inhibited the formation of granulation tissue even after 21 days [4].
Effect of halopredone acetate on rat liver tryptophan oxygenase and tyrosine aminotransferase activities [5].

Biological context of THS-201

Clinical investigation of halopredone acetate, a new topical steroid, in dermatology. Controlled study [6].

References

Comparative study of the vasoconstrictor activity of halopredone acetate in a modified McKenzie test. Rampini, E., Rastelli, A., Cardo, P. Eur. J. Clin. Pharmacol. (1978) [Pubmed]
A fifty-two-week chronic toxicity study of halopredone acetate (THS-201) in dogs. Yamashita, K., Yada, H., Irimura, K., Hayashi, T., Morinaga, H., Morita, K. The Journal of toxicological sciences. (1986) [Pubmed]
Colorimetric detection of glutamine synthetase-catalyzed transferase activity in glucocorticoid-treated skeletal muscle cells. Santoro, J.C., Harris, G., Sitlani, A. Anal. Biochem. (2001) [Pubmed]
Selective local anti-inflammatory activity of THS-201, a new intra-articular steroid, in cotton pellet granuloma and monoarticular arthritis. Kiniwa, M., Miyake, H. Archives internationales de pharmacodynamie et de thérapie. (1986) [Pubmed]
Effect of halopredone acetate on rat liver tryptophan oxygenase and tyrosine aminotransferase activities. Netti, C., Bianchetti, A., Pecile, A. Arzneimittel-Forschung. (1977) [Pubmed]
Clinical investigation of halopredone acetate, a new topical steroid, in dermatology. Controlled study. Palmerio, B., Magnani, P. Arzneimittel-Forschung. (1977) [Pubmed]

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