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Chemical Compound Review:

Powmyl propan-2-ylN-(3,4- diethoxyphenyl)carbamate

Synonyms: powmil, Diethofencarb, Powmyl WP, SureCN22967, S-165, ...

Fujimura, M. et al., Leroux, P. et al., Hosokawa, S. et al.

Leroux, Fritz, Debieu, Albertini, Lanen, Bach, Gredt, Chapeland,

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High impact information on Powmyl WP

We have previously shown that increased sensitivity to diethofencarb in the carbendazim(MBC)-resistant F914 strain of Neurospora crassa is caused by a single amino-acid change in beta-tubulin, 198Glu to Gly [1].
Amino-acid alterations in the beta-tubulin gene of Neurospora crassa that confer resistance to carbendazim and diethofencarb [1].
Two types of benzimidazole-resistant strains (Ben R1 and Ben R2) could be detected; negative cross-resistance to phenylcarbamates (e.g. diethofencarb) was only found in Ben R1 [2].
Effects of diethofencarb on thyroid function and hepatic UDP-glucuronyltransferase activity in rats [3].

References

Amino-acid alterations in the beta-tubulin gene of Neurospora crassa that confer resistance to carbendazim and diethofencarb. Fujimura, M., Kamakura, T., Inoue, H., Yamaguchi, I. Curr. Genet. (1994) [Pubmed]
Mechanisms of resistance to fungicides in field strains of Botrytis cinerea. Leroux, P., Fritz, R., Debieu, D., Albertini, C., Lanen, C., Bach, J., Gredt, M., Chapeland, F. Pest Manag. Sci. (2002) [Pubmed]
Effects of diethofencarb on thyroid function and hepatic UDP-glucuronyltransferase activity in rats. Hosokawa, S., Nakamura, J., Murakami, M., Ineyama, M., Watanabe, T., Yoshioka, K., Yamada, T., Seki, T., Okuno, Y., Yamada, H. The Journal of toxicological sciences. (1992) [Pubmed]

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