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Chemical Compound Review:

Glycylleucine (2S)-2-(2- aminoethanoylamino)-4- methyl...

Synonyms: Gly-Leu, Glycyl-leucine, Gly-L-Leu, H-Gly-Leu-OH, CHEMBL56119, ...

Norén, O. et al., Adibi, S.A. et al., Oleinik, V.M., Arvanitakis, C., Adibi, S.A. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Glycyl-leucine

Several dipeptidases such as glycyl-leucine, leucyl-glycine, glycyl-glycine and valyl-proline hydrolase activities were lower in patients with inflammatory bowel disease than in controls [1].

High impact information on Glycyl-leucine

Development of a radiochemical assay for glycyl-leucine dipeptidase in human B- and T-lymphocytes [2].
The activity of the other brush border peptidase studied, the gamma-glutamyl transpeptidase (EC 2.3.2.2), had a maximum at proximal jejunum, like the two cytosol dipeptidases glycyl-leucine dipeptidase (EC 3.4.13.2) and proline dipeptidase (EC 3.4.13.9) [3].
The activities of amylase, total proteases, monoglyceride lipase, glycyl-leucine dipeptidase and sucrase were investigated in mucosa from five consecutive parts of small intestine in blue fox, mink, ferret and rat [4].
Nephrectomy resulted in greater accumulations of glycylsarcosine in tissues and the appearance of glycylglycine in the remaining three tissues and glycyl-leucine in muscle [5].
4. The changes in plasma concentrations of free amino acids, glucose and glucagon, and tissue concentrations of free amino acids, were similar after the intravenous administration of glycyl-leucine and an equimolar mixture of free glycine and leucine [6].

References

Abnormalities of jejunal mucosal enzymes in ulcerative colitis and Crohn's disease. Arvanitakis, C. Digestion (1979) [Pubmed]
Development of a radiochemical assay for glycyl-leucine dipeptidase in human B- and T-lymphocytes. Karim, A., Kelly, G.J., Murphy, R.F., Elmore, D.T., Bridges, J.M. Biochem. Soc. Trans. (1980) [Pubmed]
Peptidase activities in the functioning jejunum and ileum before and after jejunoileal bypass in morbid obesity. Norén, O., Sjöström, H., Gudmand-Høyer, E., Skovbjerg, H., Andersen, B. Scand. J. Gastroenterol. (1980) [Pubmed]
Distribution of digestive enzyme activities along intestine in blue fox, mink, ferret and rat. Oleinik, V.M. Comp. Biochem. Physiol. A Physiol. (1995) [Pubmed]
Effect of nephrectomy and enterectomy on plasma clearance of intravenously administered dipeptides in rats. Adibi, S.A., Krzysik, B.A. Clinical science and molecular medicine. (1977) [Pubmed]
Metabolism of intravenously administered dipeptides in rats: effects on amino acid pools, glucose concentration and insulin and glucagon secretion. Adibi, S.A., Krzysik, B.A., Drash, A.L. Clinical science and molecular medicine. (1977) [Pubmed]

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