Disease relevance of Lucidil

• In a study aimed toward developing new, selective antimuscarinic drugs with potential utility in the treatment of urinary incontinence associated with bladder muscle instability, a series of N-substituted 5-(aminomethyl)-3,3-diphenyl-2(3H)-furanones, conformationally-constrained lactone relatives of benactyzine, was prepared [1].
• Benactyzine is used to treat organophosphate poisoning and drofenine acts on smooth muscle to stop muscle spasms [2].
• Benactyzine-induced mydriasis was also determined for its possible role in photophobic-induced errors [3].

Psychiatry related information on Lucidil

• Clozapine, chlorpromazine, thioridazine, atropine, scopolamine, benactyzine, yohimbine, idazoxan and cyproheptadine produced dose-dependent increases in response latency under the hind paw lick-only condition but did not increase latencies when the hind paw lick-or-jump endpoint was used [4].
• Cocaine increased both locomotor activity and fixed-interval responding at comparable doses, whereas 10-fold higher doses of benactyzine were required to increase locomotor activity [5].
• Specific characteristics of cholinergic mechanisms of short-term memory in monkeys for different types of visual information: the effects of amizil [6].

High impact information on Lucidil

• These experiments provide evidence that receptor-bound conformation II for benactyzine is preferred over conformation I in providing competitive binding with the muscarinic receptor [7].
• A repeated acquisition procedure was used with cynomolgus monkeys to test the effects of one anticholinesterase (physostigmine) and two anticholinergic (atropine and benactyzine) compounds on learning and performance [8].
• The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of trimedoxime bromide [9].
• 2. Trials were preceded by intramuscular injection of an anticholinergic drug, benactyzine hydrochloride, in doses of 0.0, 0.6, 1.0, 2.0, and 3.0 mg/kg [10].
• Therapy of intoxication with GV compound (in dose of 2x LD50) in rats demonstrated the best antidotal effect of combination of benactyzine, atropine and HI-6 [11].

Biological context of Lucidil

• Maximum protection, as determined by a shift of the LD50 for the two OP agents, was observed with the cholinolytic benactyzine [12].
• Our experiments assess the time course and severity of benactyzine effects on visual acuity for static and moving targets, amplitude and dynamics of accommodation, pupil response to light and the spatial contrast sensitivity function [13].

Anatomical context of Lucidil

• The activity of individual neurons of the visual cortex was recorded simultaneously in behavioral experiments on monkeys before and after the systemic administration of a blocker of M-cholinoreceptors, amizil (0.8-1.0 mg/kg) [14].
• Aminazine and amizil do not alter the directionality of the influence of the stimulation of the posterior hypothalamus on the responses of the visual cortex; however, they do significantly attenuate the degree of expressivity and the dynamics of this influence [15].

Associations of Lucidil with other chemical compounds

• Both drugs were competitive inhibitors of BChE and the Ki values of benactyzine and drofenine were calculated to be 0.010 +/- 0.001 and 0.003 +/- 0.000 mM, respectively, using the Systat (version 5.03, 1991) nonlinear regression analysis software package [2].
• When the pretreatment included four components (pyridostigmine, A, M and B), the LD50 of Soman was raised 30.8 times in rabbits [16].
• Shifts in spatial synchronization of rabbit cortex potentials elicited by application of acetylcholine and amizil to the visual cortex [17].
• When a small amount of sodium ion was applied to the taenia before or after the treatment with the antispasmodics, the relaxation in response to papaverine was augmented, but those in response to Aspaminol and benactyzine were not affected [18].

Analytical, diagnostic and therapeutic context of Lucidil

• Delayed discrimination of shape, contrast, and size worsened after treatment with amizil at a dose of 0.45-0.50 mg/kg, while decreases in the duration of short-term storage of information relating to color started after amizil doses of 0.6-0.8 mg/kg [6].

References