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Chemical Compound Review:

Topicon (6R,8S,10S,11S,13S,14S)-2- bromo-6,9...

Synonyms: Halopredon, Halopredona, Halopredonum, KST-1A6331, AR-1A7068, ...

Casilli, L. et al., Toscano, L. et al., Toscano, L. et al., Bianchetti, A. et al.

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High impact information on Halopredon

High local activity with no side effects, equivalent to that of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), is obtained when either the 17- or 21-OH of halopredone are benzoylated [1].
A toxicological study of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-dien-3,20-dione(halopredone acetate; Topicon), a new topical antiinflammatory steroid, administered a laboratory animals, was carried out in order to evaluate the safety of this compound [2].

Associations of Halopredon with other chemical compounds

The topical antiinflammatory activity of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon) has been compared with those of other steroids in a few bioassays in animals [3].

Analytical, diagnostic and therapeutic context of Halopredon

Physico-chemical, spectroscopic (UV, CD, ORD, IR-1H-DMR, 19F-NMR, PFT13C-NMR, MS), and chromatographic (TLC, HPLC) properties of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon) are reported [4].

References

New esters of Halopredone for topical antiinflammatory use. Toscano, L., Grisanti, G., Bianchetti, A., Bossoni, G. Arzneimittel-Forschung. (1977) [Pubmed]
Toxicological studies on halopredone acetate. Casilli, L., Sauro, M., Biraschi, L.M., Tarantino, P., Michelazzi, L. Arzneimittel-Forschung. (1977) [Pubmed]
Pharmacology of halopredone acetate, a new topical antiinflammatory steroid. Bianchetti, A., Bossoni, G., Guarneri, L., Giudici, L., Riva, M. Arzneimittel-Forschung. (1977) [Pubmed]
Physico-chemical and analytical studies on Halopredone acetate. Toscano, L., Guadagnini, G., Grisanti, G. Arzneimittel-Forschung. (1977) [Pubmed]

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