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Chemical Compound Review:

Evasprin 1-phenyl-2-(pyridin-2- ylamino)ethanol

Synonyms: Bonapar, Evasprine, Vilexin, Cabral, Evaspirine, ...

Wang, J. et al., Crouzy, S. et al., Boggs, B. et al., Smith, A.G. et al., Sarsam, M.A., et al.

Köksal, Köklü, Filik, Sasmaz, Sahin,

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Disease relevance of Analexin

Iron overload causes inhibition of hepatic uroporphyrinogen decarboxylase (UROD) and uroporphyria in C57BL/10ScSn but not DBA/2 mice [Smith, Cabral, Carthew, Francis and Manson (1989) Int. J. Cancer 43, 492-496] [1].
Phenyramidol-associated liver toxicity [2].
SETTINGS/LOCATION: CENISMI/Robert Reid Cabral Hospital, Santo Domingo, Dominican Republic. SUBJECTS: HIV+ children ages 2-8 years [3].

High impact information on Analexin

Eight strains of Chinese hamster ovary (CHO) cells having an assembly-defective beta-tubulin were found among revertants of strain Cmd 4, a mutant with a conditional lethal mutation in a beta-tubulin gene (F. Cabral, M. E. Sobel, and M. M. Gottesman, Cell 20:29-36, 1980) [4].
1. Cytochrome P/450-dependent mixed function oxidations of hexobarbital, phenyramidol, and alprenolol in intact hepatocytes were examined at different steady state oxygen concentrations [5].
The determination of the 3-D structure of the KcsA channel using X-ray crystallography (Doyle, D.A., J.M. Cabral, R.A. Pfuetzner, A. Kuo, J.M. Gulbis, S.L. Cohen, B.T. Chait, and R. MacKinnon. 1998. Science. 280:69-77) has raised some issues that remain currently unresolved concerning the interpretation of these observations [6].
The occurrence and diversity of yeasts in seawater was investigated in a study site located 20 Km off Faro, Portugal, above the Alvares Cabral Trench [7].
Currently, three techniques are used for reimplantation of coronary arteries following the insertion of a composite aortic valve graft: Bentall, aortic button, and Cabral interposition graft [8].

Gene context of Analexin

The peptide acts as a soluble domain in a rapid and readily reversible manner, reflecting a more dynamic regulation of deactivation than the slow modification observed in a previous study with a larger amino-terminal peptide fragment (Morais Cabral, J.H., A. Lee, S.L. Cohen, B.T. Chait, M. Li, and R. Mackinnon. 1998. Cell. 95:649-655) [9].

References

Genetic variation of iron-induced uroporphyria in mice. Smith, A.G., Francis, J.E. Biochem. J. (1993) [Pubmed]
Phenyramidol-associated liver toxicity. Köksal, A.S., Köklü, S., Filik, L., Sasmaz, N., Sahin, B. The Annals of pharmacotherapy. (2003) [Pubmed]
Massage treatment in HIV-1 infected Dominican children: a preliminary report on the efficacy of massage therapy to preserve the immune system in children without antiretroviral medication. Shor-Posner, G., Miguez, M.J., Hernandez-Reif, M., Perez-Then, E., Fletcher, M. Journal of alternative and complementary medicine (New York, N.Y.) (2004) [Pubmed]
Mutations affecting assembly and stability of tubulin: evidence for a nonessential beta-tubulin in CHO cells. Boggs, B., Cabral, F. Mol. Cell. Biol. (1987) [Pubmed]
Gradients of O2 concentration in hepatocytes. Jones, D.P., Mason, H.S. J. Biol. Chem. (1978) [Pubmed]
Extracellular blockade of K(+) channels by TEA: results from molecular dynamics simulations of the KcsA channel. Crouzy, S., Bernèche, S., Roux, B. J. Gen. Physiol. (2001) [Pubmed]
Assessment of yeast diversity in a marine environment in the south of Portugal by microsatellite-primed PCR. Gadanho, M., Almeida, J.M., Sampaio, J.P. Antonie Van Leeuwenhoek (2003) [Pubmed]
A technique for coronary artery reimplantation in composite aortic root replacement. Sarsam, M.A. Journal of cardiac surgery. (1994) [Pubmed]
Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels. Wang, J., Myers, C.D., Robertson, G.A. J. Gen. Physiol. (2000) [Pubmed]

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