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Chemical Compound Review:

TPC-PY019 2,6-dichloropyridine-4- carboxylic acid

Synonyms: PubChem9235, zlchem 403, NSC-4466, Enamine_005327, AG-F-86274, ...

Schaffrath, U. et al., Qian, Z.G. et al., Delaney, T.P. et al., Zhang, Y. et al., Pillonel, C., et al.

Zhang, Tessaro, Lassner, Li, Pillonel, Hückelhoven, Dechert, Kogel,

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High impact information on NSC4466

Induction of PR gene expression and pathogen resistance by the SA analog 2,6-dichloroisonicotinic acid (INA) was blocked in tga6-1 tga2-1 tga5-1 but not in tga6-1 or tga2-1 tga5-1 plants [1].
The corresponding plant defensin gene was induced after treatment of leaves with methyl jasmonate or ethylene but not with salicylic acid or 2,6-dichloroisonicotinic acid [2].
Chemical induction of resistance to Bgh by soil drench treatment with 2,6-dichloroisonicotinic acid led to down-regulation of the expression level of BI-1 [3].
2,6-Dichloroisonicotinic acid was found to bind catalase directly and inhibit its enzymatic activity [4].
To identify components of the signal transduction pathways regulating SAR, a mutant screen was developed that uses 2,6-dichloroisonicotinic acid as an activator of SAR gene expression and pathogen resistance, followed by assays for resistance to the fungal pathogen Peronospora parasitica [5].

Associations of NSC4466 with other chemical compounds

These genes also were not induced in sai1 by 2,6-dichloroisonicotinic acid (INA) or benzothiadiazole (BTH), two chemical inducers of SAR [6].
A full-length lipoxygenase cDNA (RCI-1) has been cloned from rice (Oryza sativa) whose corresponding transcripts accumulate in response to treatment of the plants with chemical inducers of acquired resistance such as benzo(1,2,3)thiadiazole-7-carbothioic acid S-methyl ester (BTH), 2,6-dichloroisonicotinic acid (INA), and probenazole [7].

Gene context of NSC4466

Two novel 2,6-dichloroisonicotinic acid (INA) derivatives [trifluoroethyl 2,6-dichloroisonicotinate (TFINA) and 2-(2,6-dichloro-pyridine-4-carbonyloxy)-ethyl jasmonate (DPCEJ)] were chemically synthesized and evaluated by bioassay as potential elicitors for inducing the biosynthesis of plant secondary metabolites [8].

Analytical, diagnostic and therapeutic context of NSC4466

Identification of a 2,6-dichloroisonicotinic-acid-sensitive protein kinase from tobacco by affinity chromatography on benzothiadiazole-sepharose and NIM-metal chelate adsorbent [9].

References

Knockout analysis of Arabidopsis transcription factors TGA2, TGA5, and TGA6 reveals their redundant and essential roles in systemic acquired resistance. Zhang, Y., Tessaro, M.J., Lassner, M., Li, X. Plant Cell (2003) [Pubmed]
Pathogen-induced systemic activation of a plant defensin gene in Arabidopsis follows a salicylic acid-independent pathway. Penninckx, I.A., Eggermont, K., Terras, F.R., Thomma, B.P., De Samblanx, G.W., Buchala, A., Métraux, J.P., Manners, J.M., Broekaert, W.F. Plant Cell (1996) [Pubmed]
Overexpression of barley BAX inhibitor 1 induces breakdown of mlo-mediated penetration resistance to Blumeria graminis. Hückelhoven, R., Dechert, C., Kogel, K.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Induction, modification, and transduction of the salicylic acid signal in plant defense responses. Chen, Z., Malamy, J., Henning, J., Conrath, U., Sánchez-Casas, P., Silva, H., Ricigliano, J., Klessig, D.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance. Delaney, T.P., Friedrich, L., Ryals, J.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene. Shah, J., Tsui, F., Klessig, D.F. Mol. Plant Microbe Interact. (1997) [Pubmed]
Characterization of RCI-1, a chloroplastic rice lipoxygenase whose synthesis is induced by chemical plant resistance activators. Schaffrath, U., Zabbai, F., Dudler, R. Eur. J. Biochem. (2000) [Pubmed]
Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites. Qian, Z.G., Zhao, Z.J., Xu, Y., Qian, X., Zhong, J.J. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
Identification of a 2,6-dichloroisonicotinic-acid-sensitive protein kinase from tobacco by affinity chromatography on benzothiadiazole-sepharose and NIM-metal chelate adsorbent. Pillonel, C. Pest Manag. Sci. (2001) [Pubmed]

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