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Chemical Compound Review:

SureCN22883 2-amino-8-methyl-3,7- dihydropurin-6-one

Synonyms: SureCN160586, AG-E-69363, SureCN7616444, NSC-22745, Oprea1_230634, ...

Xu, Y. et al., Augusto, O. et al., Gasparutto, D. et al.

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Disease relevance of AI3-50262

Excision of 8-methylguanine site-specifically incorporated into oligonucleotide substrates by the AlkA protein of Escherichia coli [1].

High impact information on AI3-50262

The thermal stability of a G-quartet formed by incorporation of 8-methylguanine (m8G) in the DNA sequence at the 5' terminus of the Rb gene was examined by CD melting experiments [2].

Analytical, diagnostic and therapeutic context of AI3-50262

The structure of 8-methylguanine, a product not previously reported in enzymatic systems, was confirmed by HPLC chromatography, UV absorbance, and mass spectrometry [3].

References

Excision of 8-methylguanine site-specifically incorporated into oligonucleotide substrates by the AlkA protein of Escherichia coli. Gasparutto, D., Dhérin, C., Boiteux, S., Cadet, J. DNA Repair (Amst.) (2002) [Pubmed]
Structural and functional characterizations of the G-quartet and i-motif elements in retinoblastoma susceptibility genes (Rb). Xu, Y., Sugiyama, H. Nucleic acids symposium series (2004) (2005) [Pubmed]
Formation of 8-methylguanine as a result of DNA alkylation by methyl radicals generated during horseradish peroxidase-catalyzed oxidation of methylhydrazine. Augusto, O., Cavalieri, E.L., Rogan, E.G., RamaKrishna, N.V., Kolar, C. J. Biol. Chem. (1990) [Pubmed]

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