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Chemical Compound Review:

PubChem19604 1-chloro-2,3,4,5,6- pentafluoro-benzene

Synonyms: CCRIS 2394, AG-B-42207, AG-K-69486, ACMC-209i7c, ANW-27862, ...

Rietjens, I.M. et al., Kinkead, E.R. et al., Clewell, H.J. et al., Kinkead, E.R. et al.

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Disease relevance of Chloroperfluorobenzene

Chloropentafluorobenzene: short-term inhalation toxicity, genotoxicity and physiologically-based pharmacokinetic model development [1].

High impact information on Chloroperfluorobenzene

This was done mainly by studying the in vitro and in vivo biotransformation of pentafluorochlorobenzene using 19F NMR [2].
Effects of a 13-week chloropentafluorobenzene inhalation exposure of Fischer 344 rats and B6C3F1 mice [3].
Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene [4].

Associations of Chloroperfluorobenzene with other chemical compounds

Identification of the metabolites formed in vivo from pentafluorochlorobenzene demonstrated that the fluorine atom para with respect to the chlorine substituent was preferentially eliminated during biotransformation [2].
In vitro studies on the biotransformation of pentafluorochlorobenzene demonstrated that defluorination was oxygen dependent and resulted in formation neither of 2,3,5,6-tetrafluoro-1-chlorobenzene nor of an amount of hydroxylated metabolites that could account for the fluoride anion formation [2].

References

Chloropentafluorobenzene: short-term inhalation toxicity, genotoxicity and physiologically-based pharmacokinetic model development. Kinkead, E.R., Wall, H.G., Hixson, C.J., Tice, R.R., Kutzman, R.S., Vinegar, A. Toxicology and industrial health. (1990) [Pubmed]
A new hypothesis for the mechanism for cytochrome P-450 dependent aerobic conversion of hexahalogenated benzenes to pentahalogenated phenols. Rietjens, I.M., Vervoort, J. Chem. Res. Toxicol. (1992) [Pubmed]
Effects of a 13-week chloropentafluorobenzene inhalation exposure of Fischer 344 rats and B6C3F1 mice. Kinkead, E.R., Bunger, S.K., Kimmel, E.C., Flemming, C.D., Wall, H.G., Grabau, J.H. Toxicology and industrial health. (1991) [Pubmed]
Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene. Clewell, H.J., Jarnot, B.M. Risk Anal. (1994) [Pubmed]

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