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Chemical Compound Review

SureCN274906     4-(2-methylaminoethyl)phenol

Synonyms: AG-F-29859, CHEBI:17458, HMDB03633, ANW-58674, NSC-113958, ...
 
 
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Disease relevance of WIN 5582

 

High impact information on WIN 5582

 

Biological context of WIN 5582

  • The nitrosation products of N-methyltyramine were p-hydroxy-m-nitro-N-nitroso-N-methyl-2-phenylethylamine and p-hydroxy-N-nitroso-N-methyl-2-phenylethylamine [5].
 

Gene context of WIN 5582

 

Analytical, diagnostic and therapeutic context of WIN 5582

  • The dose of NMT giving maximal gastrin-releasing activity was 25 microg/kg, and the 50% effective dose was approximately 10 microg/kg on oral administration to rats [6].

References

  1. Evidence that N-methyltyramine does not cause Phalaris aquatica-related sudden death in ruminants. Bourke, C., Colegate, S., Culvenor, R. Aust. Vet. J. (2006) [Pubmed]
  2. Analysis and prediction of absorption profile including hepatic first-pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by gastrointestinal-transit-absorption model. Kimura, T., Iwasaki, N., Yokoe, J.I., Haruta, S., Yokoo, Y., Ogawara, K.I., Higaki, K. Drug Metab. Dispos. (2000) [Pubmed]
  3. Cactus alkaloids XXXIII: beta-phenethylamines from the Guatemalan cactus Pilosocereus maxonii. Pummangura, S., Nichols, D.E., McLaughlin, J.L. Journal of pharmaceutical sciences. (1977) [Pubmed]
  4. Toxicity of Palicourea marcgravii: combined effects of fluoroacetate, N-methyltyramine and 2-methyltetrahydro-beta-carboline. Kemmerling, W. Z. Naturforsch., C, J. Biosci. (1996) [Pubmed]
  5. Nitrosation of N-methyltyramine and N-methyl-3-aminomethylindole, two barley malt alkaloids. Mangino, M.M., Libbey, L.M., Scanlan, R.A. IARC Sci. Publ. (1982) [Pubmed]
  6. Isolation from beer and structural determination of a potent stimulant of gastrin release. Yokoo, Y., Kohda, H., Kusumoto, A., Naoki, H., Matsumoto, N., Amachi, T., Suwa, Y., Fukazawa, H., Ishida, H., Tsuji, K., Nukaya, H. Alcohol Alcohol. (1999) [Pubmed]
 
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