Disease relevance of TTF

• Concerning the toxicity of two compounds used as mediators in biosensor devices: 7,7,8,8-tetracyanoquinodimethane (TCNQ) and tetrathiafulvalene (TTF) [1].

High impact information on TTF

• Salts of extended tetrathiafulvalene analogues: relationships between molecular structure, electrochemical properties and solid state organisation [2].
• O2- production in J774.16 cells was inhibited by some agents known to block mitochondrial electron transport before coenzyme Q, such as rotenone and tetrathiafulvalene, whereas antimycin A enhanced O2- production [3].
• Ferrocene and its derivatives, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with cyclodextrins, they can be used in enzymatic assays and in the construction of mediated biosensors [4].
• An analogy of an ion-selective electrode sensor based on the voltammetry of microcrystals of tetracyanoquinodimethane or tetrathiafulvalene adhered to an electrode surface [5].
• A new dissymmetrical tetrathiafulvalene (TTF) derivative 1 was synthesized as a versatile building block to reach TTF-based donor-acceptor assemblies incorporating C(60) in triad C(60)-TTF-C(60) 2 and/or p-benzoquinone (Q) in fused dyad Q-TTF 3 and triad Q-TTF-C(60) 4 [6].

Associations of TTF with other chemical compounds

• Novel fused D-A dyad and A-D-A triad incorporating tetrathiafulvalene and p-benzoquinone [7].
• 4,4'(5')-Bis[2-(9-anthryloxy)ethylthio]tetrathiafulvalene bearing an electron-rich tetrathiafulvalene unit and a luminophore of anthracene shows a highly selective and sensitive chemiluminescence response to singlet oxygen [8].
• Silver dendritic nanostructures protected by tetrathiafulvalene (TTF) were synthesized via reduction of silver ions with TTF in acetonitrile [9].
• Synthesis, electrochemistry and self-assembled monolayers of novel tetrathiafulvalene (TTF) and pi-extended TTF (exTTF) disulfides [10].
• A B3LYP/6-31G(d,p) and MP2/6-31G(d,p)//B3LYP/6-31G(d,p) computational study of the gas-phase complexation of cyclobis(paraquat-p-phenylene) (1(4+)) with four typical aromatic guests, namely, 1,4-dimethoxybenzene (2), 1,5-dimethoxynaphthalene (3), benzidine (4), and tetrathiafulvalene (5), has been carried out [11].

Gene context of TTF

• We report the use of the electron-donating 4,5-dipentyl-4'-methyl-TTF (TTF = tetrathiafulvalene) moiety in combination with the electron acceptor 11,11,12,12-tetracyanoanthraquinodimethane (TCNAQ) unit in the novel D-sigma-A diad molecules 11, 17, and 18 [12].
• A donor-acceptor dyad system involving tetrathiafulvalene (TTF) as donor attached by a flexible spacer to perylene-3,4:9,10-bis(dicarboximide) (PDI) as acceptor was synthesized and characterized [13].
• In situ STM study of potential-dependent height change of a tetrathiafulvalene derivative embedded in alkanethiol self-assembled monolayers on Au(111) [14].
• A bienzyme biosensor for the simultaneous determination of glucose and fructose was developed by coimmobilising glucose oxidase (GOD), fructose dehydrogenase (FDH), and the mediator, tetrathiafulvalene (TTF), by cross-linking with glutaraldehyde atop a 3-mercaptopropionic acid (MPA) self-assembled monolayer (SAM) on a gold disk electrode (AuE) [15].

Analytical, diagnostic and therapeutic context of TTF

• Steady-state and time-resolved spectroscopies clearly show an electron transfer process from pi-extended tetrathiafulvalene, covalently attached to one of the cyclopeptides, to photoexcited [60]fullerene, located on the complementary cyclopeptide [16].
• Tetrathiafulvalene derivatives as NLO-phores: synthesis, electrochemistry, Raman spectroscopy, theoretical calculations, and NLO properties of novel TTF-derived donor-pi-acceptor dyads [17].
• A study by spectroelectrochemical FTIR and density functional theory calculations of the reversible complexing ability of an electroactive tetrathiafulvalene crown [18].
• Electroactive tetrathiafulvalene thiol islands embedded in an n-alkanethiol SAM matrix were studied under potential control using in situ scanning tunneling microscopy [14].

References