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Gene Review

Grwd1  -  glutamate-rich WD repeat containing 1

Mus musculus

Synonyms: A301, AI504353, Glutamate-rich WD repeat-containing protein 1, Grwd, Protein A301, ...
 
 
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Disease relevance of Grwd1

  • The compounds A-301 and A-303 showed lethality at a high dose of 50 micrograms per mouse in C57BL/6 mice sensitized with D-galactosamine, whereas A-305 caused toxicity even at a dose of 10 micrograms per mouse [1].
 

High impact information on Grwd1

  • Although the antitumor activity of the acyl-GlcN-4P linked KDO was weaker than that of the natural lipopolysaccharide, groups of mice administered A-301 with di-3-hexadecanoyloxytetradecanoyl [(R)C14-O-C16] at C-2, -3, and A-303 with di-3-tetradecanoyloxytetradecanoyl [(R)C14-O-C14] showed longer mean survival times than the control group [2].

References

  1. Biological activities of chemically synthesized 2-keto-3-deoxyoctonic acid-(alpha 2----6)-D-glucosamine analogs of lipid A. Shimizu, T., Akiyama, S., Masuzawa, T., Yanagihara, Y., Nakamoto, S., Achiwa, K. Infect. Immun. (1987) [Pubmed]
  2. Antitumor activity, mitogenicity, and lethal toxicity of chemically synthesized monosaccharide analogs of lipid A. Shimizu, T., Masuzawa, T., Yanagihara, Y., Nakamoto, S., Itoh, H., Achiwa, K. J. Pharmacobio-dyn. (1988) [Pubmed]
 
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