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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CDK2AP2  -  cyclin-dependent kinase 2 associated...

Homo sapiens

Synonyms: CDK2-associated protein 2, Cyclin-dependent kinase 2-associated protein 2, DOC-1-related protein, DOC-1R, DOC1R, ...
 
 
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High impact information on CDK2AP2

  • The volume estimates in newborn and p14 mice suggest that the overgrowth in mceph/mceph hippocampus starts between birth and the second week of life [1].
  • Using human p12(DOC-1/CDK2AP1) as a bait in a liver cDNA library screening, cDNA clones identical to human DOC-1R transcript were identified [2].
  • RT-PCR-SSCP analysis failed to detect deleterious mutations of the DOC-1R transcript in four premalignant oral keratinocyte lines and 20 different cancer cell lines from tumor types which frequently harbor LOH at chromosome 11q13 [3].

References

  1. Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement. Almgren, M., Persson, A.S., Fenghua, C., Witgen, B.M., Schalling, M., Nyengaard, J.R., Lavebratt, C. Hippocampus (2007) [Pubmed]
  2. Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). Buajeeb, W., Zhang, X., Ohyama, H., Han, D., Surarit, R., Kim, Y., Wong, D.T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. Zhang, X., Tsao, H., Tsuji, T., Minoshima, S., McBride, J., Majewski, P., Todd, R., Shimizu, N., Wong, D.T., Housman, D.E., Haluska, F.G. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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