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Gene Review

KATNB1  -  katanin p80 (WD repeat containing) subunit...

Homo sapiens

Synonyms: Katanin p80 WD40 repeat-containing subunit B1, Katanin p80 subunit B1, p80 katanin
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High impact information on KATNB1

  • These experiments, combined with MEI-1 and MEI-2's similarity to p60 and p80 katanin, suggest that the C. elegans proteins function as a complex [1].
  • Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin [2].
  • The N-terminal WD40 domain of p80 katanin acts as a negative regulator of microtubule disassembly activity and is also required for spindle pole localization, possibly through interactions with another spindle-pole protein [2].

Other interactions of KATNB1


  1. MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis. Srayko, M., Buster, D.W., Bazirgan, O.A., McNally, F.J., Mains, P.E. Genes Dev. (2000) [Pubmed]
  2. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. McNally, K.P., Bazirgan, O.A., McNally, F.J. J. Cell. Sci. (2000) [Pubmed]
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