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MRVI1  -  murine retrovirus integration site 1 homolog

Homo sapiens

Synonyms: IRAG, Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, JAW1-related protein MRVI1, JAW1L, Protein MRVI1
 
 
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Disease relevance of MRVI1

  • One new site, Mrvi1 was identified that was disrupted by MRV in two of the leukemias [1].
  • Taken together, these data suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation [1].
 

High impact information on MRVI1

  • Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta [2].
  • IRAG was found in many tissues including aorta, trachea and uterus, and was localized perinuclearly after heterologous expression in COS-7 cells [2].
  • Bradykinin-stimulated calcium release was not affected by the expression of either IRAG or cGKIbeta, which we tested in the absence and presence of cGMP [2].
  • PKG Ibeta, but not Ialpha, binds to the general transcriptional regulator TFII-I and the inositol 1,4,5-trisphosphate receptor-associated PKG substrate IRAG [3].
  • Reverse transcriptase-PCR revealed IRAG mRNA expression in human colon, rectum, and cultured colonic smooth muscle cells [4].
 

Biological context of MRVI1

 

Anatomical context of MRVI1

  • Recently, IRAG (inositol 1,4,5-trisphophate receptor-associated cGMP kinase substrate) has been characterized as a novel target molecule of cGMP-dependent protein kinase (cGKI) mediating NO-/cGMP-dependent inhibition of inositol 1,4,5-trisphosphate (InsP(3))-dependent calcium release in transfected COS cells [4].
  • Within hematopoietic cells, Mrvi1 expression is restricted to megakaryocytes and some myeloid leukemias [1].
  • Mrvi1 encodes a novel protein with homology to Jaw1, a lymphoid restricted type II membrane protein that localizes to the endoplasmic reticulum [1].
 

Associations of MRVI1 with chemical compounds

  • Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta [5].
  • Two IRAG data submissions suggest that the fluorescein leakage assay shows promise as a screening test for surfactants and alcohols [6].
 

Physical interactions of MRVI1

  • IRAG is present in a macromolecular complex with the InsP(3) receptor type I (InsP(3)RI) and cGKIbeta [5].
 

Other interactions of MRVI1

References

  1. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. Shaughnessy, J.D., Largaespada, D.A., Tian, E., Fletcher, C.F., Cho, B.C., Vyas, P., Jenkins, N.A., Copeland, N.G. Oncogene (1999) [Pubmed]
  2. Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Schlossmann, J., Ammendola, A., Ashman, K., Zong, X., Huber, A., Neubauer, G., Wang, G.X., Allescher, H.D., Korth, M., Wilm, M., Hofmann, F., Ruth, P. Nature (2000) [Pubmed]
  3. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. Casteel, D.E., Boss, G.R., Pilz, R.B. J. Biol. Chem. (2005) [Pubmed]
  4. InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. Fritsch, R.M., Saur, D., Kurjak, M., Oesterle, D., Schlossmann, J., Geiselhöringer, A., Hofmann, F., Allescher, H.D. J. Biol. Chem. (2004) [Pubmed]
  5. Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta. Ammendola, A., Geiselhöringer, A., Hofmann, F., Schlossmann, J. J. Biol. Chem. (2001) [Pubmed]
  6. IRAG working group 3. Cell function-based assays. Interagency Regulatory Alternatives Group. Botham, P., Osborne, R., Atkinson, K., Carr, G., Cottin, M., van Buskirk, R.G. Food Chem. Toxicol. (1997) [Pubmed]
 
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