Gene Review:
ABCA10 - ATP-binding cassette, sub-family A (ABC1),...
Homo sapiens
Synonyms:
ATP-binding cassette sub-family A member 10, EST698739
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.
Read more.
Welcome to WikiGenes!
If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.
Much of the current information on this page has been automatically compiled from Pubmed.
This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!
WikiGenes is a non-profit and open access community project - Read more.
High impact information on ABCA10
- Our results identify ABCA10 as a novel member of the group of ABCA6-like transporters and suggest its involvement in macrophage lipid homeostasis [1].
- In this study, we report the cloning of an additional ABC A subfamily transporter, denoted ABCA10, from macrophages [1].
- ABCA10 mRNA is expressed in similar quantities in monocytes and M-CSF differentiated macrophages [1].
- Moreover, we identified seven single nucleotide polymorphisms in ABCA10 transcripts [1].
- Analysis of the gene structure demonstrated that the ABCA10 gene consists of 40 exons that extend across a genomic region of approximately 97kb size (Chr. 17q24.3) [1].
Biological context of ABCA10
- Like other transporters of this subfamily, ABCA10 mRNA is ubiquitously expressed and highest gene expression levels are detectable in heart, brain, and the gastrointestinal tract [1].
Anatomical context of ABCA10
- Several distinct ABCA10 transcripts are expressed in human macrophages that predict the existence of various truncated forms of the novel transporter [1].
Associations of ABCA10 with chemical compounds
- Importantly, ABCA10 expression is suppressed by cholesterol import into macrophages, indicating that it is a cholesterol-responsive gene [1].
References
- ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter. Wenzel, J.J., Kaminski, W.E., Piehler, A., Heimerl, S., Langmann, T., Schmitz, G. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg