Gene Review:
topA - DNA topoisomerase I
Escherichia coli CFT073
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Disease relevance of topA
- We previously reported that the P1 promoter of topA encoding topoisomerase I of Escherichia coli is activated in response to oxidative stress, in a Fis-dependent manner [1].
High impact information on topA
- DNase I footprinting show that Fis binds the promoter region of topA at eight sites with different affinities [1].
References
- Differential regulation of Escherichia coli topoisomerase I by Fis. Weinstein-Fischer, D., Altuvia, S. Mol. Microbiol. (2007) [Pubmed]
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