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Gene Review

Fbxw11  -  F-box and WD-40 domain protein 11

Mus musculus

Synonyms: 2310065A07Rik, AA536858, BTRC2, BTRCP2, Btrcp2, ...
 
 
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Disease relevance of Fbxw11

  • CONCLUSIONS: Our findings demonstrate that the GH-RH antagonist MZ-4-71 can significantly inhibit the growth of SK-ES-1 and MNNG/HOS osteosarcomas in mice [1].
  • In the absence of the promoter, administration of HOS for only 1 month induced no hepatomas; 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene alone induced only a low incidence [2].
  • HOS cells did not form any tumors even in the presence of HTLV-I or Tax1 [3].
  • The GFP tagged 143B cells (and to a lesser extent, MNNG/HOS cells) were readily recovered from lung metastases [4].
  • In this study, the authors investigated the effects of the GH-RH antagonist JV-1-38 on MNNG/HOS human osteosarcoma and SK-ES-1 human Ewing sarcoma cell lines [5].
 

Psychiatry related information on Fbxw11

 

High impact information on Fbxw11

 

Chemical compound and disease context of Fbxw11

 

Biological context of Fbxw11

 

Anatomical context of Fbxw11

  • Specific high-affinity receptors for somatostatin and epidermal growth factor were found on membranes of MNNG/HOS tumors but not on SK-ES-1 tumors [8].
  • Therefore, we have studied the time- and maturation-dependent expression of MEPE in two human osteoblast culture systems, the osteosarcoma cell line HOS 58 and primary trabecular osteoblasts [15].
  • Electron microscopic studies show that PbCrO4 is phagocytosed by HOS cells and accumulates within the vacuoles in the cytoplasm [10].
  • When GFP-tagged osteosarcoma cells were injected into the proximal tibia of athymic mice, we found that 143B cells were highly tumorigenic and metastatic, and MNNG/HOS cells were tumorigenic but significantly less metastatic [4].
  • Intriguingly, even when a filter was interposed between monocytes and HOS cells, polykaryocytes also appeared [16].
 

Associations of Fbxw11 with chemical compounds

  • In cell cultures, the proliferation rate of MNNG/HOS cells, but not of SK-ES-1, was significantly suppressed by RC-160 [8].
  • The inert metal tantalum oxide did not enhance HOS transformation frequency above untreated levels [12].
  • The hepatocarcinogen 1'-hydroxysafrole (HOS) exhibited weak initiating activity and strong promoting activity for the induction of enzyme-altered foci and tumors in rat liver [2].
  • Thus, administration of a single dose of HOS to rats 18 h after a 70% hepatectomy, followed by administration of phenobarbital (PB) in the diet for 6 months, induced a low, but statistically significant, number of foci of enzyme-altered cells [2].
  • Large numbers of enzyme-altered foci developed when HOS was administered in the diet at levels of 0.05-0.25% to rats previously administered a single dose of N,N-diethylnitrosamine (DEN) 24 h after a 70% hepatectomy [2].
 

Analytical, diagnostic and therapeutic context of Fbxw11

References

  1. Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. Pinski, J., Schally, A.V., Groot, K., Halmos, G., Szepeshazi, K., Zarandi, M., Armatis, P. J. Natl. Cancer Inst. (1995) [Pubmed]
  2. Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver. Boberg, E.W., Liem, A., Miller, E.C., Miller, J.A. Carcinogenesis (1987) [Pubmed]
  3. Rapid tumor formation and development of neutrophilia and splenomegaly in nude mice transplanted with human cells expressing human T cell leukemia virus type I or Tax1. Soda, Y., Jinno, A., Tanaka, Y., Akagi, T., Shimotohno, K., Hoshino, H. Leukemia (2000) [Pubmed]
  4. An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis. Luu, H.H., Kang, Q., Park, J.K., Si, W., Luo, Q., Jiang, W., Yin, H., Montag, A.G., Simon, M.A., Peabody, T.D., Haydon, R.C., Rinker-Schaeffer, C.W., He, T.C. Clin. Exp. Metastasis (2005) [Pubmed]
  5. Inhibition of proliferation in human MNNG/HOS osteosarcoma and SK-ES-1 Ewing sarcoma cell lines in vitro and in vivo by antagonists of growth hormone-releasing hormone: effects on insulin-like growth factor II. Braczkowski, R., Schally, A.V., Plonowski, A., Varga, J.L., Groot, K., Krupa, M., Armatis, P. Cancer (2002) [Pubmed]
  6. Human recipient cell for oncogene transfection studies. Tainsky, M.A., Shamanski, F.L., Blair, D., Vande Woude, G. Mol. Cell. Biol. (1987) [Pubmed]
  7. Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. Bhatia, N., Herter, J.R., Slaga, T.J., Fuchs, S.Y., Spiegelman, V.S. Oncogene (2002) [Pubmed]
  8. Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice. Pinski, J., Schally, A.V., Halmos, G., Szepeshazi, K., Groot, K. Int. J. Cancer (1996) [Pubmed]
  9. Gemcitabine inhibits viability, growth, and metastasis of osteosarcoma cell lines. Ando, T., Ichikawa, J., Okamoto, A., Tasaka, K., Nakao, A., Hamada, Y. J. Orthop. Res. (2005) [Pubmed]
  10. Induction of morphological transformation, anchorage-independent growth and plasminogen activators in non-tumorigenic human osteosarcoma cells by lead chromate. Sidhu, M.K., Fernandez, C., Khan, M.Y., Kumar, S. Anticancer Res. (1991) [Pubmed]
  11. Inhibition of HOS expression and activities by Wnt pathway. Spiegelman, V.S., Tang, W., Katoh, M., Slaga, T.J., Fuchs, S.Y. Oncogene (2002) [Pubmed]
  12. Neoplastic transformation of human osteoblast cells to the tumorigenic phenotype by heavy metal-tungsten alloy particles: induction of genotoxic effects. Miller, A.C., Mog, S., McKinney, L., Luo, L., Allen, J., Xu, J., Page, N. Carcinogenesis (2001) [Pubmed]
  13. Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. Naruse, T., Nishida, Y., Hosono, K., Ishiguro, N. Carcinogenesis (2006) [Pubmed]
  14. Characterization of receptors for growth hormone-releasing hormone in human osteosarcomas and Ewing's sarcomas. Halmos, G., Schally, A.V., Bernardino, A.L., Varga, J.L. Int. J. Oncol. (2006) [Pubmed]
  15. Evidence of downregulation of matrix extracellular phosphoglycoprotein during terminal differentiation in human osteoblasts. Siggelkow, H., Schmidt, E., Hennies, B., Hüfner, M. Bone (2004) [Pubmed]
  16. Human osteosarcoma-derived cell lines produce soluble factor(s) that induces differentiation of blood monocytes to osteoclast-like cells. Miyamoto, N., Higuchi, Y., Mori, K., Ito, M., Tsurudome, M., Nishio, M., Yamada, H., Sudo, A., Kato, K., Uchida, A., Ito, Y. Int. Immunopharmacol. (2002) [Pubmed]
  17. Reduction of spermatogenesis and steroidogenesis in mice after fentin and fenbutatin administration. Reddy, P.S., Pushpalatha, T., Reddy, P.S. Toxicol. Lett. (2006) [Pubmed]
 
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