Disease relevance of alr

• The protein was overexpressed in Escherichia coli, and serine racemase activity was detected in the membrane but not in the cytoplasmic fraction after centrifugation of sonicated cells, whereas alanine racemase activity was located almost exclusively in the cytoplasm [1].
• Comparative modelling of the deduced C-terminal domain was based on the alignment of VanT with the Air alanine racemase from Bacillus stearothermophilus [1].
• A new sterility test for cow's milk using alanine racemase gene as the index [2].
• The psychrotrophic alanine racemase from Pseudomonas fluorescens, a typical psychrotroph, is less resistant to organic solvents than the enzymes from thermophilic and mesophilic bacteria (Okubo et al., J. Home Econ. Jpn., 46: 1135-1140, 1995) [3].

High impact information on alr

• A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis [4].
• It is concluded that TOXG encodes an alanine racemase whose function is to synthesize D-Ala for incorporation into HC-toxin [4].
• The serine racemase activity was partially (64%) inhibited by D-cycloserine, whereas host alanine racemase activity was almost totally inhibited (97%) [1].
• The most effective of these extragenic suppressors conferred an elevated alanine racemase activity which was resistant to the effects of pyridoxal removal [5].
• Both D- and L-alanine were intrinsically active as inducers of alanine racemase synthesis [6].

Chemical compound and disease context of alr

• To further elucidate this difference, we examined the effect of ethyl alcohol on the growth and intracellular alanine racemase activity of three typical psychrotrophs-P. fluorescens, Bacillus psychrosaccharolyticus and B. psychrophilus-in comparison with two mesophiles, Escherichia coli and B. subtilis [3].

Biological context of alr

• The alanine racemase gene sequenced was found to contain an open reading frame of 1158 nucleotides [7].
• Oligonucleotide primers designed from consensus sequences of alanine racemase genes were used for a sterility test of cow's milk by polymerase chain reaction (PCR) [2].

Associations of alr with chemical compounds

• The synthesis of both D-alanine dehydrogenase and alanine racemase was found to be regulated by catabolite repression [6].
• Effect of ethyl alcohol on growth and intracellular alanine racemase of psychrotrophs [3].

References