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Gene Review

uhpT  -  sugar phosphate antiporter

Escherichia coli CFT073

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Disease relevance of uhpT

  • To evaluate anion exchange as the mechanistic basis of sugar phosphate transport, natural and artificial membranes were used in studies of glucose 6-phosphate (Glc-6-P) and inorganic phosphate (Pi) accumulation by the uhpT-encoded protein (UhpT) of Escherichia coli [1].

High impact information on uhpT


Chemical compound and disease context of uhpT


Biological context of uhpT

  • Strains carrying uhp-lac operon fusions in which lac operon expression is under the control of the uhpT promoter were isolated [8].
  • A plasmid carrying only uhpT conferred transport activity in a host strain deleted for the uhp region [9].
  • Mapping experiments were consistent with the gene order pyrE-gltS-uhpTRA-ilvB, where uhpT encodes the transport system and uhpR and uhpA are regulatory genes whose products are necessary for proper uhp regulation [10].
  • Location of the gene specifying hexose phosphate transport (uhp) on the chromosome of Escherichia coli [11].

Associations of uhpT with chemical compounds

  • It is hypothesized that glucose 6-phosphate binding to these membranes is due to a uhpR-directed, membrane-bound receptor which functions in regulation of the inducible uhpT gene product: the hexose phosphate permease [12].
  • Subsequently, this phosphoryl group is transferred to a conserved aspartate residue in the response-regulator UhpA, which then initiates uhpT transcription, via binding to the uhpT promoter region [13].
  • Evidence is presented that the glycerol phosphate and hexose phosphate transport systems are not important inorganic phophate transport systems [14].
  • A mutant was selected that will grow rapidly on glucosamine 6-phosphate because it contains a constitutive hexose phosphate transport system [7].


  1. The mechanism of glucose 6-phosphate transport by Escherichia coli. Sonna, L.A., Ambudkar, S.V., Maloney, P.C. J. Biol. Chem. (1988) [Pubmed]
  2. Involvement of the amino-terminal phosphorylation module of UhpA in activation of uhpT transcription in Escherichia coli. Webber, C.A., Kadner, R.J. Mol. Microbiol. (1997) [Pubmed]
  3. Cooperativity in signal transfer through the Uhp system of Escherichia coli. Verhamme, D.T., Postma, P.W., Crielaard, W., Hellingwerf, K.J. J. Bacteriol. (2002) [Pubmed]
  4. The phosphoryl transfer domain of UhpB interacts with the response regulator UhpA. Wright, J.S., Kadner, R.J. J. Bacteriol. (2001) [Pubmed]
  5. Effect of altered spacing between uhpT promoter elements on transcription activation. Chen, Q., Kadner, R.J. J. Bacteriol. (2000) [Pubmed]
  6. Interplay between the membrane-associated UhpB and UhpC regulatory proteins. Island, M.D., Kadner, R.J. J. Bacteriol. (1993) [Pubmed]
  7. Growth of Escherichia coli on glucosamine 6-phosphate: selection of a constitutive hexose phosphate transport system mutant. Dietz, G.W. Can. J. Microbiol. (1978) [Pubmed]
  8. Exogenous induction of the Escherichia coli hexose phosphate transport system defined by uhp-lac operon fusions. Shattuck-Eidens, D.M., Kadner, R.J. J. Bacteriol. (1981) [Pubmed]
  9. Role of uhp genes in expression of the Escherichia coli sugar-phosphate transport system. Weston, L.A., Kadner, R.J. J. Bacteriol. (1988) [Pubmed]
  10. Genetic control of the hexose phosphate transport system of Escherichia coli: mapping of deletion and insertion mutations in the uhp region. Kadner, R.J., Shattuck-Eidens, D.M. J. Bacteriol. (1983) [Pubmed]
  11. Location of the gene specifying hexose phosphate transport (uhp) on the chromosome of Escherichia coli. Essenberg, R.C., Kornberg, H.L. J. Gen. Microbiol. (1977) [Pubmed]
  12. uhp-directed, glucose 6-phosphate membrane receptor in Escherichia coli. Goldenbaum, P.E., Farmer, K.S. J. Bacteriol. (1980) [Pubmed]
  13. Glucose-6-phosphate-dependent phosphoryl flow through the Uhp two-component regulatory system. Verhamme, D.T., Arents, J.C., Postma, P.W., Crielaard, W., Hellingwerf, K.J. Microbiology (Reading, Engl.) (2001) [Pubmed]
  14. A mutant of Escherichia coli auxotrophic for organic phosphates: evidence for two defects in inorganic phosphate transport. Sprague, G.F., Bell, R.M., Cronan, J.E. Mol. Gen. Genet. (1975) [Pubmed]
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