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Gene Review:

For1 - formamidase 1

Mus musculus

This record was discontinued.

Ueda, O. et al., Shinohara, R. et al., Tatsumi, K. et al., Dobrovolsky, V.N. et al., Cumming, R.B. et al.

Dobrovolsky, Bowyer, Pabarcus, Heflich, Williams, Doerge, Arvidsson, Bergquist, Casida,

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High impact information on For1

The experiments with rat liver preparations showed that the liver cytosolic N-formylating and N-acetylating activities are due to formamidase and arylamine acetyltransferase, respectively [1].
Deacylation of these compounds appear to be mainly catalyzed by carboxylesterase in liver microsomes and formamidase in liver cytosol [2].
2-Formylaminofluorene, 2-acetylaminofluorene, 1-formylaminopyrene, 4-formylaminobiphenyl, 2-formylaminonaphthalene, 1-formylaminonaphthalene, and 2-acetylaminofluorene were deacylated by formamidase purified from rat liver cytosol [2].
However, there was 13% residual formyl-kynurenine hydrolysis in the kidney of KO mice, suggesting the existence of a formamidase other than Afmid [3].
Genetics of formamidase-5 (brain formamidase) in the mouse: localization of the structural gene on chromosome 14 [4].

Biological context of For1

New formamidase having substrate specificity for o-formylaminoacetophenone in pig liver [5].

Anatomical context of For1

In contrast, the activity of liver cytosol was inhibited by diisopropyl fluorophosphate, an inhibitor of formamidase [2].

Associations of For1 with chemical compounds

When formylkynurenine was used as substrate, two peaks of formamidase activity were observed but, with formylaminoacetophenone as substrate, only one peak was observed [5].

References

Comparative study on metabolic formation of N-arylformamides and N-arylacetamides from carcinogenic arylamines in mammalian species. Tatsumi, K., Kitamura, S., Amano, H., Ueda, K. Cancer Res. (1989) [Pubmed]
Deacylation of N-arylformamides and N-arylacetamides by formamidase in rat liver. Ueda, O., Kitamura, S., Ohta, S. Drug Metab. Dispos. (2002) [Pubmed]
Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype. Dobrovolsky, V.N., Bowyer, J.F., Pabarcus, M.K., Heflich, R.H., Williams, L.D., Doerge, D.R., Arvidsson, B., Bergquist, J., Casida, J.E. Biochim. Biophys. Acta (2005) [Pubmed]
Genetics of formamidase-5 (brain formamidase) in the mouse: localization of the structural gene on chromosome 14. Cumming, R.B., Walton, M.F., Fuscoe, J.C., Taylor, B.A., Womack, J.E., Gaertner, F.H. Biochem. Genet. (1979) [Pubmed]
New formamidase having substrate specificity for o-formylaminoacetophenone in pig liver. Shinohara, R., Ishiguro, I. Biochim. Biophys. Acta (1977) [Pubmed]

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