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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Adcy4  -  adenylate cyclase 4

Mus musculus

Synonyms: ATP pyrophosphate-lyase 4, Adenylate cyclase type 4, Adenylate cyclase type IV, Adenylyl cyclase 4
 
 
 
 
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High impact information on Adcy4

  • Furthermore, the underlying defect leading to AC-4 deficiency and forskolin-resistance can be overcome by transfection of mutant clones with expression vectors encoding G beta/gamma [1].
  • These data support our hypothesis that AC-4 is a preferred target of forskolin action in Y1 cells, demonstrate novel roles for G beta/gamma in gene expression and indicate that a common underlying defect, suppressible by G beta/gamma, accounts for both the resistance to ACTH and to forskolin [1].
 

Other interactions of Adcy4

  • These studies demonstrate roles for Sp1/Sp3 and SF1 in Adcy4 expression in Y1 cells and establish a repressor function for SF1 in certain promoter contexts [2].

References

  1. Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells. Rui, X., Al-Hakim, A., Tsao, J., Albert, P.R., Schimmer, B.P. Mol. Cell. Endocrinol. (2004) [Pubmed]
  2. Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells. Rui, X., Tsao, J., Scheys, J.O., Hammer, G.D., Schimmer, B.P. Endocrinology (2008) [Pubmed]
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