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Cdc42ep1  -  CDC42 effector protein (Rho GTPase binding) 1

Mus musculus

Synonyms: 1810058K22Rik, AA980734, Binder of Rho GTPases 5, Borg5, CEP1, ...
 
 
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Disease relevance of Cdc42ep1

  • Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1 [1].
 

High impact information on Cdc42ep1

  • These results reveal a role of Cdc42GAP in mammalian perinatal growth and implicate the c-Jun N-terminal kinase-mediated apoptosis machinery as a Cdc42 effector pathway in vivo [2].
  • Towards this end, we performed a two-hybrid screen using the TC10 GTPase as bait and identified a family of putative effector proteins related to MSE55, a murine stromal and epithelial cell protein of 55 kDa [3].

References

  1. Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Li, S., Wang, Q., Chakladar, A., Bronson, R.T., Bernards, A. Mol. Cell. Biol. (2000) [Pubmed]
  2. Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. Wang, L., Yang, L., Burns, K., Kuan, C.Y., Zheng, Y. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty, G., Perlungher, R.R., Macara, I.G. Mol. Cell. Biol. (1999) [Pubmed]
 
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