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Gene Review

Tdp1  -  tyrosyl-DNA phosphodiesterase 1

Mus musculus

Synonyms: 2810481F14Rik, 4921509N21Rik, AI838772, AW493413, E430034L06Rik, ...
 
 
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High impact information on Tdp1

  • We have developed GFScan(Gene Family Scan), a tool that identifies members of a gene family by searching genomic DNA sequences with genomic DNA motifs (or matrices) that are representative of the family [1].
  • After postnatal exposure, reduced Immobility with increased Social Investigation and Explore and Scan occurred at 5 and 15 weeks, at 25 weeks valproate increased Social Investigation in males encountering females and at 30 weeks enhanced Aggression in pair-housed males [2].
 

Analytical, diagnostic and therapeutic context of Tdp1

  • Whole mounts were stained by indirect immunofluorescence and then examined using a Zeiss Laser Scan Microscope. We found that each ECM component examined had a distinct distribution and that the distribution of some molecules varied with culture time [3].

References

  1. GFScan: a gene family search tool at genomic DNA level. Xuan, Z., McCombie, W.R., Zhang, M.Q. Genome Res. (2002) [Pubmed]
  2. Sodium valproate: effects on social behaviour and physical development in the mouse. Chapman, J.B., Cutler, M.G. Psychopharmacology (Berl.) (1984) [Pubmed]
  3. Localization of extracellular matrix components in developing mouse salivary glands by confocal microscopy. Hardman, P., Spooner, B.S. Anat. Rec. (1992) [Pubmed]
 
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